Hairy cell Leukemia, Version 2.2018

Clinical practice guidelines in oncology

William G. Wierda, John C. Byrd, Jeremy S. Abramson, Seema Bhat, Robert G Bociek, Danielle Brander, Jennifer Brown, Asher Chanan-Khan, Steve E. Coutre, Randall S. Davis, Christopher D. Fletcher, Brian Hill, Brad S. Kahl, Manali Kamdar, Lawrence D. Kaplan, Nadia Khan, Thomas J. Kipps, Jeffrey Lancet, Shuo Ma, Sami Malek & 6 others Claudio Mosse, Mazyar Shadman, Tanya Siddiqi, Deborah Stephens, Nina Wagner, Andrew D. Zelenetz

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Hairy cell leukemia (HCL) is a rare type of indolent B-cell leukemia, characterized by symptoms of fatigue and weakness, or-ganomegaly, pancytopenia, and recurrent opportunistic infections. Classic HCL should be considered a distinct clinical entity separate from HCLvariant (HCLv), which is associated with a more aggressive disease course and may not respond to standard HCL therapies. Somatic hypermutation in the IGHV gene is present in most patients with HCL. The BRAF V600E mutation has been reported in most patients with classic HCL but not in those with other B-cell leukemias or lymphomas. Therefore, it is necessary to distinguish HCLv from classic HCL. This manuscript discusses the recommendations outlined in the NCCN Guidelines for the diagnosis and management of classic HCL.

Original languageEnglish (US)
Pages (from-to)1414-1427
Number of pages14
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume15
Issue number11
DOIs
StatePublished - Nov 1 2017
Externally publishedYes

Fingerprint

Hairy Cell Leukemia
Practice Guidelines
B-Cell Leukemia
Pancytopenia
Opportunistic Infections
B-Cell Lymphoma
Cell- and Tissue-Based Therapy
Fatigue
Guidelines
Mutation
Genes

ASJC Scopus subject areas

  • Oncology

Cite this

Hairy cell Leukemia, Version 2.2018 : Clinical practice guidelines in oncology. / Wierda, William G.; Byrd, John C.; Abramson, Jeremy S.; Bhat, Seema; Bociek, Robert G; Brander, Danielle; Brown, Jennifer; Chanan-Khan, Asher; Coutre, Steve E.; Davis, Randall S.; Fletcher, Christopher D.; Hill, Brian; Kahl, Brad S.; Kamdar, Manali; Kaplan, Lawrence D.; Khan, Nadia; Kipps, Thomas J.; Lancet, Jeffrey; Ma, Shuo; Malek, Sami; Mosse, Claudio; Shadman, Mazyar; Siddiqi, Tanya; Stephens, Deborah; Wagner, Nina; Zelenetz, Andrew D.

In: JNCCN Journal of the National Comprehensive Cancer Network, Vol. 15, No. 11, 01.11.2017, p. 1414-1427.

Research output: Contribution to journalReview article

Wierda, WG, Byrd, JC, Abramson, JS, Bhat, S, Bociek, RG, Brander, D, Brown, J, Chanan-Khan, A, Coutre, SE, Davis, RS, Fletcher, CD, Hill, B, Kahl, BS, Kamdar, M, Kaplan, LD, Khan, N, Kipps, TJ, Lancet, J, Ma, S, Malek, S, Mosse, C, Shadman, M, Siddiqi, T, Stephens, D, Wagner, N & Zelenetz, AD 2017, 'Hairy cell Leukemia, Version 2.2018: Clinical practice guidelines in oncology', JNCCN Journal of the National Comprehensive Cancer Network, vol. 15, no. 11, pp. 1414-1427. https://doi.org/10.6004/jnccn.2017.0165
Wierda, William G. ; Byrd, John C. ; Abramson, Jeremy S. ; Bhat, Seema ; Bociek, Robert G ; Brander, Danielle ; Brown, Jennifer ; Chanan-Khan, Asher ; Coutre, Steve E. ; Davis, Randall S. ; Fletcher, Christopher D. ; Hill, Brian ; Kahl, Brad S. ; Kamdar, Manali ; Kaplan, Lawrence D. ; Khan, Nadia ; Kipps, Thomas J. ; Lancet, Jeffrey ; Ma, Shuo ; Malek, Sami ; Mosse, Claudio ; Shadman, Mazyar ; Siddiqi, Tanya ; Stephens, Deborah ; Wagner, Nina ; Zelenetz, Andrew D. / Hairy cell Leukemia, Version 2.2018 : Clinical practice guidelines in oncology. In: JNCCN Journal of the National Comprehensive Cancer Network. 2017 ; Vol. 15, No. 11. pp. 1414-1427.
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AU - Bhat, Seema

AU - Bociek, Robert G

AU - Brander, Danielle

AU - Brown, Jennifer

AU - Chanan-Khan, Asher

AU - Coutre, Steve E.

AU - Davis, Randall S.

AU - Fletcher, Christopher D.

AU - Hill, Brian

AU - Kahl, Brad S.

AU - Kamdar, Manali

AU - Kaplan, Lawrence D.

AU - Khan, Nadia

AU - Kipps, Thomas J.

AU - Lancet, Jeffrey

AU - Ma, Shuo

AU - Malek, Sami

AU - Mosse, Claudio

AU - Shadman, Mazyar

AU - Siddiqi, Tanya

AU - Stephens, Deborah

AU - Wagner, Nina

AU - Zelenetz, Andrew D.

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