Hair dyes and risk of glioma among Nebraska women

Ellen F. Heineman, Mary H. Ward, Rodney D McComb, Dennis D. Weisenburger, Shelia Hoar Zahm

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The etiology of brain cancer is not well understood. We conducted a population-based case-control study among 112 white women in Nebraska who were newly diagnosed with glioma between July 1988 and June 1993, and 215 controls, to identify risk factors for this disease. A 1.7-fold increased risk of glioma was observed for women who ever used hair coloring products (95% confidence interval (CI) = 1.0-2.9, 62 cases), and a 2.4-fold risk for those who used permanent hair coloring products (odds ratio (OR) = 2.4, 95% CI = 1.3-4.5, 39 cases). For women with the most aggressive form of glioma, glioblastoma multiforme, risk increased with duration of exposure to 4.9 (95% CI = 1.6-15.7, 10 cases) after 21 or more years of permanent hair coloring use. Higher risks were observed with earlier age at first use, but we did not see an exposure-response pattern with frequency of use of permanent dyes. No association was observed with use of non-permanent (sometimes called temporary or semi-permanent) hair coloring products. These suggestive findings need confirmation in future studies with larger sample sizes, fewer proxy respondents, and the ability to evaluate the effect of changes in formulations over time.

Original languageEnglish (US)
Pages (from-to)857-864
Number of pages8
JournalCancer Causes and Control
Volume16
Issue number7
DOIs
StatePublished - Sep 1 2005

Fingerprint

Hair Dyes
Glioma
Hair
Confidence Intervals
Proxy
Glioblastoma
Brain Neoplasms
Sample Size
Case-Control Studies
Coloring Agents
Odds Ratio
Population

Keywords

  • Brain cancer
  • Glioma
  • Hair dyes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Heineman, E. F., Ward, M. H., McComb, R. D., Weisenburger, D. D., & Zahm, S. H. (2005). Hair dyes and risk of glioma among Nebraska women. Cancer Causes and Control, 16(7), 857-864. https://doi.org/10.1007/s10552-005-3204-z

Hair dyes and risk of glioma among Nebraska women. / Heineman, Ellen F.; Ward, Mary H.; McComb, Rodney D; Weisenburger, Dennis D.; Zahm, Shelia Hoar.

In: Cancer Causes and Control, Vol. 16, No. 7, 01.09.2005, p. 857-864.

Research output: Contribution to journalArticle

Heineman, EF, Ward, MH, McComb, RD, Weisenburger, DD & Zahm, SH 2005, 'Hair dyes and risk of glioma among Nebraska women', Cancer Causes and Control, vol. 16, no. 7, pp. 857-864. https://doi.org/10.1007/s10552-005-3204-z
Heineman, Ellen F. ; Ward, Mary H. ; McComb, Rodney D ; Weisenburger, Dennis D. ; Zahm, Shelia Hoar. / Hair dyes and risk of glioma among Nebraska women. In: Cancer Causes and Control. 2005 ; Vol. 16, No. 7. pp. 857-864.
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