Guidelines for the prevention and treatment of B-virus infections in exposed persons

B Virus Working Group

Research output: Contribution to journalReview article

103 Citations (Scopus)

Abstract

Cercopithecine herpesvirus 1 (B virus), enzootic among monkeys of the genus Macaca, causes minimal morbidity in its natural host. In contrast, human B-virus infection presents as rapidly ascending encephalomyelitis with a fatality rate of A70%. This infection remains an uncommon result of macaque-related injuries, although the increase in the use of macaques for research on simian retrovirus infection and hepatitis has expanded the number of opportunities for human exposure. In response to this situation, Emory University and the Centers for Disease Control and Prevention jointly sponsored a B Virus Working Group to formulate a rational approach to the detection and management of human B-virus infection. The resulting guidelines are presented herein and are based upon information from published cases, unpublished cases managed by working-group members, knowledge of the behavior of herpes simplex virus, and in the absence of hard datathe collective judgment of the group. Although consensus among the coauthors existed on the major points covered by these guidelines, opinions varied widely regarding specific recommendations.

Original languageEnglish (US)
Pages (from-to)421-439
Number of pages19
JournalClinical Infectious Diseases
Volume20
Issue number2
DOIs
StatePublished - Feb 1995

Fingerprint

Cercopithecine Herpesvirus 1
Virus Diseases
Guidelines
Macaca
Simian Retroviruses
Retroviridae Infections
Encephalomyelitis
Simplexvirus
Centers for Disease Control and Prevention (U.S.)
Hepatitis
Haplorhini
Consensus
Morbidity
Wounds and Injuries
Infection
Research

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Guidelines for the prevention and treatment of B-virus infections in exposed persons. / B Virus Working Group.

In: Clinical Infectious Diseases, Vol. 20, No. 2, 02.1995, p. 421-439.

Research output: Contribution to journalReview article

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abstract = "Cercopithecine herpesvirus 1 (B virus), enzootic among monkeys of the genus Macaca, causes minimal morbidity in its natural host. In contrast, human B-virus infection presents as rapidly ascending encephalomyelitis with a fatality rate of A70{\%}. This infection remains an uncommon result of macaque-related injuries, although the increase in the use of macaques for research on simian retrovirus infection and hepatitis has expanded the number of opportunities for human exposure. In response to this situation, Emory University and the Centers for Disease Control and Prevention jointly sponsored a B Virus Working Group to formulate a rational approach to the detection and management of human B-virus infection. The resulting guidelines are presented herein and are based upon information from published cases, unpublished cases managed by working-group members, knowledge of the behavior of herpes simplex virus, and in the absence of hard datathe collective judgment of the group. Although consensus among the coauthors existed on the major points covered by these guidelines, opinions varied widely regarding specific recommendations.",
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AU - Holmes, Gary

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AU - Lopez, Carlos

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AU - Oxman, Michael N.

AU - Pellett, Phillip E.

AU - Richardson, John H.

AU - Silberman, Morton S.

AU - Soike, Kenneth

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AU - Stewart, John A.

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AU - Warren, Mc Wilson

AU - Wells, Diana

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N2 - Cercopithecine herpesvirus 1 (B virus), enzootic among monkeys of the genus Macaca, causes minimal morbidity in its natural host. In contrast, human B-virus infection presents as rapidly ascending encephalomyelitis with a fatality rate of A70%. This infection remains an uncommon result of macaque-related injuries, although the increase in the use of macaques for research on simian retrovirus infection and hepatitis has expanded the number of opportunities for human exposure. In response to this situation, Emory University and the Centers for Disease Control and Prevention jointly sponsored a B Virus Working Group to formulate a rational approach to the detection and management of human B-virus infection. The resulting guidelines are presented herein and are based upon information from published cases, unpublished cases managed by working-group members, knowledge of the behavior of herpes simplex virus, and in the absence of hard datathe collective judgment of the group. Although consensus among the coauthors existed on the major points covered by these guidelines, opinions varied widely regarding specific recommendations.

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