Guidelines for experimental models of myocardial ischemia and infarction

Merry L. Lindsey, Roberto Bolli, John M. Canty, Xiao Jun Du, Nikolaos G. Frangogiannis, Stefan Frantz, Robert G. Gourdie, Jeffrey W. Holmes, Steven P. Jones, Robert A. Kloner, David J. Lefer, Ronglih Liao, Elizabeth Murphy, Peipei Ping, Karin Przyklenk, Fabio A. Recchia, Lisa Schwartz Longacre, Crystal M. Ripplinger, Jennifer E. Van Eyk, Gerd Heusch

Research output: Contribution to journalReview article

79 Citations (Scopus)

Abstract

Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial ischemia with or without reperfusion, and basic and translational research is needed to better understand its underlying mechanisms and consequences for cardiac structure and function. Ischemia underlies a broad range of clinical scenarios ranging from angina to hibernation to permanent occlusion, and while reperfusion is mandatory for salvage from ischemic injury, reperfusion also inflicts injury on its own. In this consensus statement, we present recommendations for animal models of myocardial ischemia and infarction. With increasing awareness of the need for rigor and reproducibility in designing and performing scientific research to ensure validation of results, the goal of this review is to provide best practice information regarding myocardial ischemia-reperfusion and infarction models.

Original languageEnglish (US)
Pages (from-to)H812-H838
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume314
Issue number4
DOIs
StatePublished - Apr 2018

Fingerprint

Myocardial Ischemia
Theoretical Models
Myocardial Infarction
Guidelines
Reperfusion
Hibernation
Myocardial Reperfusion
Translational Medical Research
Reperfusion Injury
Practice Guidelines
Ischemia
Animal Models
Wounds and Injuries
Research

Keywords

  • Animal models
  • Cardiac remodeling
  • Heart failure
  • Myocardial infarction
  • Reperfusion
  • Rigor and reproducibility

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Guidelines for experimental models of myocardial ischemia and infarction. / Lindsey, Merry L.; Bolli, Roberto; Canty, John M.; Du, Xiao Jun; Frangogiannis, Nikolaos G.; Frantz, Stefan; Gourdie, Robert G.; Holmes, Jeffrey W.; Jones, Steven P.; Kloner, Robert A.; Lefer, David J.; Liao, Ronglih; Murphy, Elizabeth; Ping, Peipei; Przyklenk, Karin; Recchia, Fabio A.; Longacre, Lisa Schwartz; Ripplinger, Crystal M.; Van Eyk, Jennifer E.; Heusch, Gerd.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 314, No. 4, 04.2018, p. H812-H838.

Research output: Contribution to journalReview article

Lindsey, ML, Bolli, R, Canty, JM, Du, XJ, Frangogiannis, NG, Frantz, S, Gourdie, RG, Holmes, JW, Jones, SP, Kloner, RA, Lefer, DJ, Liao, R, Murphy, E, Ping, P, Przyklenk, K, Recchia, FA, Longacre, LS, Ripplinger, CM, Van Eyk, JE & Heusch, G 2018, 'Guidelines for experimental models of myocardial ischemia and infarction', American Journal of Physiology - Heart and Circulatory Physiology, vol. 314, no. 4, pp. H812-H838. https://doi.org/10.1152/ajpheart.00335.2017
Lindsey, Merry L. ; Bolli, Roberto ; Canty, John M. ; Du, Xiao Jun ; Frangogiannis, Nikolaos G. ; Frantz, Stefan ; Gourdie, Robert G. ; Holmes, Jeffrey W. ; Jones, Steven P. ; Kloner, Robert A. ; Lefer, David J. ; Liao, Ronglih ; Murphy, Elizabeth ; Ping, Peipei ; Przyklenk, Karin ; Recchia, Fabio A. ; Longacre, Lisa Schwartz ; Ripplinger, Crystal M. ; Van Eyk, Jennifer E. ; Heusch, Gerd. / Guidelines for experimental models of myocardial ischemia and infarction. In: American Journal of Physiology - Heart and Circulatory Physiology. 2018 ; Vol. 314, No. 4. pp. H812-H838.
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