Growth regulatory factors and carcinogenesis: The roles played by transforming growth factor β, its receptors and signaling pathways

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27 Citations (Scopus)

Abstract

It is widely recognized that growth factors play critical roles in cell proliferation and differentiation. In the early 1980s, several members of the transforming growth factor-β (TGF-β) superfamily were identified and subsequently shown to play important roles in many diseases, in particular cancer. Efforts to understand how TGF-β exerts its effects led to identification of TGF-β-receptors and several downstream signaling pathways activated by this family of growth factors. This review provides an overview of TGF-β-receptors and its downstream signaling pathways. As part of this discussion, this review indicates that inactivation of TGF-β-receptors or components of their signaling pathways is often a target during carcinogenesis and that mutations or altered expression at any step along this complex, growth regulatory pathway can lead to aberrant cell proliferation. Lastly, the Cancer Genome Anatomy Project is briefly discussed, in particular how it may help to identify aberrant growth factor expression during carcinogenesis and improve the diagnosis of cancer patients.

Original languageEnglish (US)
Pages (from-to)4791-4807
Number of pages17
JournalAnticancer Research
Volume19
Issue number6 A
StatePublished - Dec 1 1999

Fingerprint

Growth Factor Receptors
Transforming Growth Factors
Intercellular Signaling Peptides and Proteins
Carcinogenesis
Cell Proliferation
Neoplasms
Cell Differentiation
Anatomy
Genome
Mutation
Growth

Keywords

  • Breast cancer
  • Cancer Genome Anatomy Project
  • Cell cycle
  • Colorectal cancer
  • Cyclin dependent kinases
  • Cyclin-dependent kinase inhibitors
  • Cyclins
  • Glioblastoma
  • Insulin like growth factor receptor-2
  • Pancreatic cancer
  • Signal transduction pathways
  • Smad

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

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title = "Growth regulatory factors and carcinogenesis: The roles played by transforming growth factor β, its receptors and signaling pathways",
abstract = "It is widely recognized that growth factors play critical roles in cell proliferation and differentiation. In the early 1980s, several members of the transforming growth factor-β (TGF-β) superfamily were identified and subsequently shown to play important roles in many diseases, in particular cancer. Efforts to understand how TGF-β exerts its effects led to identification of TGF-β-receptors and several downstream signaling pathways activated by this family of growth factors. This review provides an overview of TGF-β-receptors and its downstream signaling pathways. As part of this discussion, this review indicates that inactivation of TGF-β-receptors or components of their signaling pathways is often a target during carcinogenesis and that mutations or altered expression at any step along this complex, growth regulatory pathway can lead to aberrant cell proliferation. Lastly, the Cancer Genome Anatomy Project is briefly discussed, in particular how it may help to identify aberrant growth factor expression during carcinogenesis and improve the diagnosis of cancer patients.",
keywords = "Breast cancer, Cancer Genome Anatomy Project, Cell cycle, Colorectal cancer, Cyclin dependent kinases, Cyclin-dependent kinase inhibitors, Cyclins, Glioblastoma, Insulin like growth factor receptor-2, Pancreatic cancer, Signal transduction pathways, Smad",
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N2 - It is widely recognized that growth factors play critical roles in cell proliferation and differentiation. In the early 1980s, several members of the transforming growth factor-β (TGF-β) superfamily were identified and subsequently shown to play important roles in many diseases, in particular cancer. Efforts to understand how TGF-β exerts its effects led to identification of TGF-β-receptors and several downstream signaling pathways activated by this family of growth factors. This review provides an overview of TGF-β-receptors and its downstream signaling pathways. As part of this discussion, this review indicates that inactivation of TGF-β-receptors or components of their signaling pathways is often a target during carcinogenesis and that mutations or altered expression at any step along this complex, growth regulatory pathway can lead to aberrant cell proliferation. Lastly, the Cancer Genome Anatomy Project is briefly discussed, in particular how it may help to identify aberrant growth factor expression during carcinogenesis and improve the diagnosis of cancer patients.

AB - It is widely recognized that growth factors play critical roles in cell proliferation and differentiation. In the early 1980s, several members of the transforming growth factor-β (TGF-β) superfamily were identified and subsequently shown to play important roles in many diseases, in particular cancer. Efforts to understand how TGF-β exerts its effects led to identification of TGF-β-receptors and several downstream signaling pathways activated by this family of growth factors. This review provides an overview of TGF-β-receptors and its downstream signaling pathways. As part of this discussion, this review indicates that inactivation of TGF-β-receptors or components of their signaling pathways is often a target during carcinogenesis and that mutations or altered expression at any step along this complex, growth regulatory pathway can lead to aberrant cell proliferation. Lastly, the Cancer Genome Anatomy Project is briefly discussed, in particular how it may help to identify aberrant growth factor expression during carcinogenesis and improve the diagnosis of cancer patients.

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KW - Cancer Genome Anatomy Project

KW - Cell cycle

KW - Colorectal cancer

KW - Cyclin dependent kinases

KW - Cyclin-dependent kinase inhibitors

KW - Cyclins

KW - Glioblastoma

KW - Insulin like growth factor receptor-2

KW - Pancreatic cancer

KW - Signal transduction pathways

KW - Smad

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