Growth of intestinal neomucosa on prosthetic materials

Jon S Thompson, P. W. Kampfe, J. R. Newland, J. A. Vanderhoof

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The short bowel syndrome is a potential complication of the surgical management of diseases of the large and small intestine. Recently methods have been examined for expanding the small bowel absorptive area using prosthetic materials. We investigated the feasibility of growing intestinal mucosa on prosthetic patches and tubes. Ileal defects were patched with a 2 × 5-cm patch of either Dacron (n = 15), polyglycolic acid mesh (PGA) (n = 9), or polytetrafluroethylene (PTFE) (n = 5) prosthesis in New Zealand white male rabbits. Gross and microscopic analysis at 2, 4, and 8 weeks revealed that the serosal surface was covered with neomucosa by 4 weeks. Dacron and PTFE grafts were either minimally attached or extruded and PGA grafts had dissolved. At 8 weeks, none of the patches were present but with all three materials the resultant area of neomucosa was only 15% of the original defect. The neomucosa was functional as determined by glucose uptake and disaccharidase activity. Three centimeter Dacron tubes were interposed in the distal ileum of 10 rabbits and in a bypassed ileal segment in 11 rabbits. There was an 80% mortality within 2 weeks, and no evidence of neomucosal growth. Although prosthetic patches support the growth of functional neomucosa, there is a minimal increase in the final surface area. The type of prosthesis did not influence the outcome. The use of Dacron tubes is associated with high mortality and no neomucosal growth. The use of prosthetic materials is not likely to be useful in the clinical management of the short bowel syndrome.

Original languageEnglish (US)
Pages (from-to)484-492
Number of pages9
JournalJournal of Surgical Research
Volume41
Issue number5
DOIs
StatePublished - Jan 1 1986

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Polyethylene Terephthalates
Polyglycolic Acid
Short Bowel Syndrome
Growth
Rabbits
Prostheses and Implants
Disaccharidases
Transplants
Mortality
Large Intestine
Intestinal Mucosa
Disease Management
Ileum
Small Intestine
Glucose

ASJC Scopus subject areas

  • Surgery

Cite this

Growth of intestinal neomucosa on prosthetic materials. / Thompson, Jon S; Kampfe, P. W.; Newland, J. R.; Vanderhoof, J. A.

In: Journal of Surgical Research, Vol. 41, No. 5, 01.01.1986, p. 484-492.

Research output: Contribution to journalArticle

Thompson, Jon S ; Kampfe, P. W. ; Newland, J. R. ; Vanderhoof, J. A. / Growth of intestinal neomucosa on prosthetic materials. In: Journal of Surgical Research. 1986 ; Vol. 41, No. 5. pp. 484-492.
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