Growth inhibition of transformed cells correlates with their junctional communication with normal cells

Parmender P. Mehta, John S. Bertram, Werner R. Loewenstein

Research output: Contribution to journalArticle

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Abstract

The growth of various chemically and virally transformed cell types in culture is inhibited when they are in contact with normal cell types. We show that this growth inhibition is contingent on the presence of junctional communication between the normal and transformed cells (heterologous communication), as probed with a 443 dalton microinjected fluorescent tracer. In cell combinations where heterologous communication is weak or absent there is no detectable growth inhibition; the inhibition appears when communication is induced by cyclic AMP-dependent phosphorylation, and only then. In cell combinations where heterologous communication is spontaneously strong, the growth inhibition is present, but it is abolished when the communication is blocked by retinol or retinoic acid. The cell-to-cell membrane channels of gap junctions are the likely conduits of the signals for this growth control.

Original languageEnglish (US)
Pages (from-to)187-196
Number of pages10
JournalCell
Volume44
Issue number1
DOIs
Publication statusPublished - Jan 17 1986

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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