Growth factors in the regenerating pancreas of γ-interferon transgenic mice

Marc Arnush, Danling Gu, Chris Baugh, Stephen P. Sawyer, Barbara Mroczkowski, Troy Krahl, Nora Sarvetnick

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

We examined the distribution of several relevant growth factors in γ- interferon transgenic mice, which undergo continual growth and differentiation in the pancreas. As a result, epidermal growth factor (EGF), TGF-α, and the EGF receptor were identified as potentially important in mediating some of these regenerative changes. Transient up-regulation of EGF, TGF-α, and the EGF receptor were observed in acinii undergoing differentiation into duct-like structures. These ducts have been shown to proliferate and potentiate regeneration of the pancreatic islet mass.

Original languageEnglish (US)
Pages (from-to)985-990
Number of pages6
JournalLaboratory Investigation
Volume74
Issue number6
Publication statusPublished - Jun 1 1996

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Arnush, M., Gu, D., Baugh, C., Sawyer, S. P., Mroczkowski, B., Krahl, T., & Sarvetnick, N. (1996). Growth factors in the regenerating pancreas of γ-interferon transgenic mice. Laboratory Investigation, 74(6), 985-990.