Growth factors in the regenerating pancreas of γ-interferon transgenic mice

Marc Arnush, Danling Gu, Chris Baugh, Stephen P. Sawyer, Barbara Mroczkowski, Troy Krahl, Nora E Sarvetnick

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

We examined the distribution of several relevant growth factors in γ- interferon transgenic mice, which undergo continual growth and differentiation in the pancreas. As a result, epidermal growth factor (EGF), TGF-α, and the EGF receptor were identified as potentially important in mediating some of these regenerative changes. Transient up-regulation of EGF, TGF-α, and the EGF receptor were observed in acinii undergoing differentiation into duct-like structures. These ducts have been shown to proliferate and potentiate regeneration of the pancreatic islet mass.

Original languageEnglish (US)
Pages (from-to)985-990
Number of pages6
JournalLaboratory Investigation
Volume74
Issue number6
StatePublished - Jun 1 1996

Fingerprint

Epidermal Growth Factor Receptor
Epidermal Growth Factor
Interferons
Transgenic Mice
Pancreas
Intercellular Signaling Peptides and Proteins
Islets of Langerhans
Regeneration
Up-Regulation
Growth

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Arnush, M., Gu, D., Baugh, C., Sawyer, S. P., Mroczkowski, B., Krahl, T., & Sarvetnick, N. E. (1996). Growth factors in the regenerating pancreas of γ-interferon transgenic mice. Laboratory Investigation, 74(6), 985-990.

Growth factors in the regenerating pancreas of γ-interferon transgenic mice. / Arnush, Marc; Gu, Danling; Baugh, Chris; Sawyer, Stephen P.; Mroczkowski, Barbara; Krahl, Troy; Sarvetnick, Nora E.

In: Laboratory Investigation, Vol. 74, No. 6, 01.06.1996, p. 985-990.

Research output: Contribution to journalArticle

Arnush, M, Gu, D, Baugh, C, Sawyer, SP, Mroczkowski, B, Krahl, T & Sarvetnick, NE 1996, 'Growth factors in the regenerating pancreas of γ-interferon transgenic mice', Laboratory Investigation, vol. 74, no. 6, pp. 985-990.
Arnush M, Gu D, Baugh C, Sawyer SP, Mroczkowski B, Krahl T et al. Growth factors in the regenerating pancreas of γ-interferon transgenic mice. Laboratory Investigation. 1996 Jun 1;74(6):985-990.
Arnush, Marc ; Gu, Danling ; Baugh, Chris ; Sawyer, Stephen P. ; Mroczkowski, Barbara ; Krahl, Troy ; Sarvetnick, Nora E. / Growth factors in the regenerating pancreas of γ-interferon transgenic mice. In: Laboratory Investigation. 1996 ; Vol. 74, No. 6. pp. 985-990.
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