Growth and development of infants with end-stage renal disease receiving long-term peritoneal dialysis

Bradley A. Warady, Margaret Kriley, Helen Lovell, Susan E. Farrell, Stanley Hellerstein

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The growth and development of four infants with end-stage renal disease receiving long-term peritoneal dialysis was studied during the first year of life. In each patient, dialysis was begun before 4 weeks of age. A nutritional regimen was designed to attain a daily weight gain appropriate for height age while minimizing the blood urea nitrogen level. A neurodevelopmental evaluation of gross and fine motor, cognitive, language, and psychosoclal skills was performed at least every 3 months. At age 1 year, the mean height standard deviation score (SDS) was -1.33±0.2. Weight for height was >95th percentile in one patient and normal in three. Mean caloric and protein intake were 105±20 kcal/kg/d (11.4±2.7 kcal/cm/d) and 2.7 g/kg/d (0.30±0.11 g/cm/d), respectively. Mean blood urea nitrogen was 53.6±17.8 mg/dL. Developmentally, three of the patients were functioning in the normal range and one was midly retarded. However, gross motor skills were delayed in all patients. Although infants with end-stage renal disease are usually severely growth retarded and developmentally delayed, our observations suggest that early nutritional intervention and dialysis can yield improved results.

Original languageEnglish (US)
Pages (from-to)714-719
Number of pages6
JournalThe Journal of Pediatrics
Volume112
Issue number5
DOIs
StatePublished - May 1988

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Peritoneal Dialysis
Growth and Development
Chronic Kidney Failure
Blood Urea Nitrogen
Dialysis
Motor Skills
Energy Intake
Weight Gain
Reference Values
Language
Weights and Measures
Growth
Proteins

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Growth and development of infants with end-stage renal disease receiving long-term peritoneal dialysis. / Warady, Bradley A.; Kriley, Margaret; Lovell, Helen; Farrell, Susan E.; Hellerstein, Stanley.

In: The Journal of Pediatrics, Vol. 112, No. 5, 05.1988, p. 714-719.

Research output: Contribution to journalArticle

Warady, Bradley A. ; Kriley, Margaret ; Lovell, Helen ; Farrell, Susan E. ; Hellerstein, Stanley. / Growth and development of infants with end-stage renal disease receiving long-term peritoneal dialysis. In: The Journal of Pediatrics. 1988 ; Vol. 112, No. 5. pp. 714-719.
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