Greater early pancreas graft loss in women compared with men after simultaneous pancreas-kidney transplantation

Christopher Colling, R. Brian Stevens, Elizabeth Lyden, James Lane, Lynn R Mack, Lucile Wrenshall, Jennifer Lynn Larsen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Gender differences in graft survival has been reported after some types of organ transplantation, but not after pancreas transplantation. This study compares graft survival between women and men after simultaneous pancreas-kidney transplantation (SPK). Methods: All first time SPK (n = 163) transplants (109 M/54 F) performed between 1989 and 2000 at University of Nebraska Medical Center, where data was available, were analyzed for overall graft and patient survival. Graft failure was then subdivided into early (<6 months), and late (>6 months), and compared between women and men. Results: The 5-yr pancreas and kidney graft survival rates for all SPK recipients was 86% [95% confidence interval (CI) = 81-92%] and 87% (95% CI = 82-93%), respectively. While overall pancreas graft survival in women was similar to men (p = 0.16), early pancreas graft failure was greater in women than men (p = 0.010) with no one cause for failure predominant. There was no gender difference in late pancreas graft failure or in early, or late kidney graft failure in the same recipients. The gender difference was unexplained by differences in age, immunosuppression, body mass index (BMI), or diabetes duration between women and men. Conclusions: This is the first report of a gender difference in pancreas graft survival after SPK with greater early (< 6 months) pancreas graft failure in women than men. With no gender difference in kidney graft failure in the same individuals, gender differences in immune responses are unlikely to be the cause. Multiple variables likely contribute.

Original languageEnglish (US)
Pages (from-to)158-161
Number of pages4
JournalClinical Transplantation
Volume19
Issue number2
DOIs
StatePublished - Apr 1 2005

Fingerprint

Pancreas Transplantation
Kidney Transplantation
Graft Survival
Pancreas
Transplants
Renal Insufficiency
Confidence Intervals
Organ Transplantation
Individuality
Immunosuppression
Body Mass Index
Survival Rate
Kidney

Keywords

  • Diabetes
  • Graft survival
  • Pancreas transplantation

ASJC Scopus subject areas

  • Transplantation

Cite this

Greater early pancreas graft loss in women compared with men after simultaneous pancreas-kidney transplantation. / Colling, Christopher; Stevens, R. Brian; Lyden, Elizabeth; Lane, James; Mack, Lynn R; Wrenshall, Lucile; Larsen, Jennifer Lynn.

In: Clinical Transplantation, Vol. 19, No. 2, 01.04.2005, p. 158-161.

Research output: Contribution to journalArticle

Colling, Christopher ; Stevens, R. Brian ; Lyden, Elizabeth ; Lane, James ; Mack, Lynn R ; Wrenshall, Lucile ; Larsen, Jennifer Lynn. / Greater early pancreas graft loss in women compared with men after simultaneous pancreas-kidney transplantation. In: Clinical Transplantation. 2005 ; Vol. 19, No. 2. pp. 158-161.
@article{d60f6ff20d814e39bbbfc05dfd48b0e3,
title = "Greater early pancreas graft loss in women compared with men after simultaneous pancreas-kidney transplantation",
abstract = "Background: Gender differences in graft survival has been reported after some types of organ transplantation, but not after pancreas transplantation. This study compares graft survival between women and men after simultaneous pancreas-kidney transplantation (SPK). Methods: All first time SPK (n = 163) transplants (109 M/54 F) performed between 1989 and 2000 at University of Nebraska Medical Center, where data was available, were analyzed for overall graft and patient survival. Graft failure was then subdivided into early (<6 months), and late (>6 months), and compared between women and men. Results: The 5-yr pancreas and kidney graft survival rates for all SPK recipients was 86{\%} [95{\%} confidence interval (CI) = 81-92{\%}] and 87{\%} (95{\%} CI = 82-93{\%}), respectively. While overall pancreas graft survival in women was similar to men (p = 0.16), early pancreas graft failure was greater in women than men (p = 0.010) with no one cause for failure predominant. There was no gender difference in late pancreas graft failure or in early, or late kidney graft failure in the same recipients. The gender difference was unexplained by differences in age, immunosuppression, body mass index (BMI), or diabetes duration between women and men. Conclusions: This is the first report of a gender difference in pancreas graft survival after SPK with greater early (< 6 months) pancreas graft failure in women than men. With no gender difference in kidney graft failure in the same individuals, gender differences in immune responses are unlikely to be the cause. Multiple variables likely contribute.",
keywords = "Diabetes, Graft survival, Pancreas transplantation",
author = "Christopher Colling and Stevens, {R. Brian} and Elizabeth Lyden and James Lane and Mack, {Lynn R} and Lucile Wrenshall and Larsen, {Jennifer Lynn}",
year = "2005",
month = "4",
day = "1",
doi = "10.1111/j.1399-0012.2004.00236.x",
language = "English (US)",
volume = "19",
pages = "158--161",
journal = "Clinical Transplantation",
issn = "0902-0063",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Greater early pancreas graft loss in women compared with men after simultaneous pancreas-kidney transplantation

AU - Colling, Christopher

AU - Stevens, R. Brian

AU - Lyden, Elizabeth

AU - Lane, James

AU - Mack, Lynn R

AU - Wrenshall, Lucile

AU - Larsen, Jennifer Lynn

PY - 2005/4/1

Y1 - 2005/4/1

N2 - Background: Gender differences in graft survival has been reported after some types of organ transplantation, but not after pancreas transplantation. This study compares graft survival between women and men after simultaneous pancreas-kidney transplantation (SPK). Methods: All first time SPK (n = 163) transplants (109 M/54 F) performed between 1989 and 2000 at University of Nebraska Medical Center, where data was available, were analyzed for overall graft and patient survival. Graft failure was then subdivided into early (<6 months), and late (>6 months), and compared between women and men. Results: The 5-yr pancreas and kidney graft survival rates for all SPK recipients was 86% [95% confidence interval (CI) = 81-92%] and 87% (95% CI = 82-93%), respectively. While overall pancreas graft survival in women was similar to men (p = 0.16), early pancreas graft failure was greater in women than men (p = 0.010) with no one cause for failure predominant. There was no gender difference in late pancreas graft failure or in early, or late kidney graft failure in the same recipients. The gender difference was unexplained by differences in age, immunosuppression, body mass index (BMI), or diabetes duration between women and men. Conclusions: This is the first report of a gender difference in pancreas graft survival after SPK with greater early (< 6 months) pancreas graft failure in women than men. With no gender difference in kidney graft failure in the same individuals, gender differences in immune responses are unlikely to be the cause. Multiple variables likely contribute.

AB - Background: Gender differences in graft survival has been reported after some types of organ transplantation, but not after pancreas transplantation. This study compares graft survival between women and men after simultaneous pancreas-kidney transplantation (SPK). Methods: All first time SPK (n = 163) transplants (109 M/54 F) performed between 1989 and 2000 at University of Nebraska Medical Center, where data was available, were analyzed for overall graft and patient survival. Graft failure was then subdivided into early (<6 months), and late (>6 months), and compared between women and men. Results: The 5-yr pancreas and kidney graft survival rates for all SPK recipients was 86% [95% confidence interval (CI) = 81-92%] and 87% (95% CI = 82-93%), respectively. While overall pancreas graft survival in women was similar to men (p = 0.16), early pancreas graft failure was greater in women than men (p = 0.010) with no one cause for failure predominant. There was no gender difference in late pancreas graft failure or in early, or late kidney graft failure in the same recipients. The gender difference was unexplained by differences in age, immunosuppression, body mass index (BMI), or diabetes duration between women and men. Conclusions: This is the first report of a gender difference in pancreas graft survival after SPK with greater early (< 6 months) pancreas graft failure in women than men. With no gender difference in kidney graft failure in the same individuals, gender differences in immune responses are unlikely to be the cause. Multiple variables likely contribute.

KW - Diabetes

KW - Graft survival

KW - Pancreas transplantation

UR - http://www.scopus.com/inward/record.url?scp=15844407841&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15844407841&partnerID=8YFLogxK

U2 - 10.1111/j.1399-0012.2004.00236.x

DO - 10.1111/j.1399-0012.2004.00236.x

M3 - Article

VL - 19

SP - 158

EP - 161

JO - Clinical Transplantation

JF - Clinical Transplantation

SN - 0902-0063

IS - 2

ER -