Great promise of tissue-resident adult stem/progenitor cells in transplantation and cancer therapies

Murielle Mimeault, Surinder Kumar Batra

Research output: Chapter in Book/Report/Conference proceedingChapter

21 Citations (Scopus)

Abstract

Recent progress in tissue-resident adult stem/progenitor cell research has inspired great interest because these immature cells from your own body can act as potential, easily accessible cell sources for cell transplantation in regenerative medicine and cancer therapies. The use of adult stem/progenitor cells endowed with a high self-renewal ability and multilineage differentiation potential, which are able to regenerate all the mature cells in the tissues from their origin, offers great promise in replacing non-functioning or lost cells and regenerating diseased and damaged tissues. The presence of a small subpopulation of adult stem/progenitor cells in most tissues and organs provides the possibility of stimulating their in vivo differentiation, or of using their ex vivo expanded progenies for cell-replacement and gene therapies with multiple applications in humans without a high-risk of graft rejection and major side effects. Among the diseases that could be treated by adult stem cell-based therapies are hematopoietic and immune disorders, multiple degenerative disorders such as Parkinson's and Alzheimer's diseases, Types 1 and 2 diabetes mellitus as well as skin, eye, liver, lung, tooth and cardiovascular disorders. In addition, a combination of the current cancer treatments with an adjuvant treatment consisting of an autologous or allogeneic adult stem/progenitor cell transplantation also represents a promising strategy for treating and even curing diverse aggressive, metastatic, recurrent and lethal cancers. In this chapter, we reviewed the most recent advancements on the characterization of phenotypic and functional properties of adult stem/progenitor cell types found in bone marrow, heart, brain and other tissues and discussed their therapeutic implications in the stem cell-based transplantation therapy.

Original languageEnglish (US)
Title of host publicationStem Cell Transplantation
Pages171-186
Number of pages16
DOIs
StatePublished - Apr 20 2012

Publication series

NameAdvances in Experimental Medicine and Biology
Volume741
ISSN (Print)0065-2598

Fingerprint

Adult Stem Cells
Cell Transplantation
Stem cells
Stem Cells
Tissue
Stem Cell Transplantation
Neoplasms
Cell- and Tissue-Based Therapy
Therapeutics
Stem Cell Research
Regenerative Medicine
Immune System Diseases
Graft Rejection
Type 1 Diabetes Mellitus
Genetic Therapy
Type 2 Diabetes Mellitus
Gene therapy
Parkinson Disease
Oncology
Tooth

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Mimeault, M., & Batra, S. K. (2012). Great promise of tissue-resident adult stem/progenitor cells in transplantation and cancer therapies. In Stem Cell Transplantation (pp. 171-186). (Advances in Experimental Medicine and Biology; Vol. 741). https://doi.org/10.1007/978-1-4614-2098-9_12

Great promise of tissue-resident adult stem/progenitor cells in transplantation and cancer therapies. / Mimeault, Murielle; Batra, Surinder Kumar.

Stem Cell Transplantation. 2012. p. 171-186 (Advances in Experimental Medicine and Biology; Vol. 741).

Research output: Chapter in Book/Report/Conference proceedingChapter

Mimeault, M & Batra, SK 2012, Great promise of tissue-resident adult stem/progenitor cells in transplantation and cancer therapies. in Stem Cell Transplantation. Advances in Experimental Medicine and Biology, vol. 741, pp. 171-186. https://doi.org/10.1007/978-1-4614-2098-9_12
Mimeault M, Batra SK. Great promise of tissue-resident adult stem/progenitor cells in transplantation and cancer therapies. In Stem Cell Transplantation. 2012. p. 171-186. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-2098-9_12
Mimeault, Murielle ; Batra, Surinder Kumar. / Great promise of tissue-resident adult stem/progenitor cells in transplantation and cancer therapies. Stem Cell Transplantation. 2012. pp. 171-186 (Advances in Experimental Medicine and Biology).
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