Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice

Tomomi Kiyota, Jatin Machhi, Yaman Lu, Bhagyalaxmi Dyavarshetty, Maryam Nemati, Izumi Yokoyama, R. Lee Mosley, Howard E. Gendelman

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We investigated the effects of granulocyte-macrophage colony stimulating factor (GM-CSF) on behavioral and pathological outcomes in Alzheimer's disease (AD) and non-transgenic mice. GM-CSF treatment in AD mice reduced brain amyloidosis, increased plasma Aβ and rescued cognitive impairment with increased hippocampal expression of calbindin and synaptophysin and increased levels of doublecortin-positive cells in the dentate gyrus. These data extend GM-CSF pleiotropic neuroprotection mechanisms in AD and include regulatory T cell-mediated immunomodulation of microglial function, Aβ clearance, maintenance of synaptic integrity, and induction of neurogenesis. Together these data support further development of GM-CSF as a neuroprotective agent for AD.

Original languageEnglish (US)
Pages (from-to)80-92
Number of pages13
JournalJournal of Neuroimmunology
Volume319
DOIs
StatePublished - Jun 15 2018

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Keywords

  • APP/PS1 mice
  • Amyloidosis
  • Aβ plaques
  • Calbindin
  • Cognitive function
  • Doublecortin
  • Hippocampus
  • Synaptophysin
  • Tregs

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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