Granulocyte-Macrophage colony stimulating factor exerts protective and immunomodulatory effects in cortical trauma

Matthew L. Kelso, Bret R. Elliott, Nicole A. Haverland, R Lee Mosley, Howard Eliot Gendelman

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Neurodegeneration after traumatic brain injury is facilitated by innate and adaptive immunity and can be harnessed to affect brain repair. In mice subjected to controlled cortical impact (CCI), we show that treatment with granulocyte macrophage colony stimulating factor (GM-CSF) affects regulatory T cell numbers in the cervical lymph nodes coincident with decreased lesion volumes and increased cortical tissue sparing. This paralleled increases in neurofilament and diminished reactive microglial staining. Transcriptomic analysis showed that GM-CSF induces robust immune neuroprotective responses seven days following CCI. Together, these results support the therapeutic potential of GM-CSF for TBI.

Original languageEnglish (US)
Pages (from-to)162-173
Number of pages12
JournalJournal of Neuroimmunology
Volume278
DOIs
StatePublished - Jan 15 2015

Fingerprint

Granulocyte-Macrophage Colony-Stimulating Factor
Wounds and Injuries
Intermediate Filaments
Adaptive Immunity
Regulatory T-Lymphocytes
Innate Immunity
Cell Count
Lymph Nodes
Staining and Labeling
Brain
Therapeutics

Keywords

  • Immunity
  • Microglia
  • Neuroinflammation
  • T cell
  • Traumatic brain injury

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Granulocyte-Macrophage colony stimulating factor exerts protective and immunomodulatory effects in cortical trauma. / Kelso, Matthew L.; Elliott, Bret R.; Haverland, Nicole A.; Mosley, R Lee; Gendelman, Howard Eliot.

In: Journal of Neuroimmunology, Vol. 278, 15.01.2015, p. 162-173.

Research output: Contribution to journalArticle

@article{df8edd2b31bb41b09c40768475f62d18,
title = "Granulocyte-Macrophage colony stimulating factor exerts protective and immunomodulatory effects in cortical trauma",
abstract = "Neurodegeneration after traumatic brain injury is facilitated by innate and adaptive immunity and can be harnessed to affect brain repair. In mice subjected to controlled cortical impact (CCI), we show that treatment with granulocyte macrophage colony stimulating factor (GM-CSF) affects regulatory T cell numbers in the cervical lymph nodes coincident with decreased lesion volumes and increased cortical tissue sparing. This paralleled increases in neurofilament and diminished reactive microglial staining. Transcriptomic analysis showed that GM-CSF induces robust immune neuroprotective responses seven days following CCI. Together, these results support the therapeutic potential of GM-CSF for TBI.",
keywords = "Immunity, Microglia, Neuroinflammation, T cell, Traumatic brain injury",
author = "Kelso, {Matthew L.} and Elliott, {Bret R.} and Haverland, {Nicole A.} and Mosley, {R Lee} and Gendelman, {Howard Eliot}",
year = "2015",
month = "1",
day = "15",
doi = "10.1016/j.jneuroim.2014.11.002",
language = "English (US)",
volume = "278",
pages = "162--173",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",

}

TY - JOUR

T1 - Granulocyte-Macrophage colony stimulating factor exerts protective and immunomodulatory effects in cortical trauma

AU - Kelso, Matthew L.

AU - Elliott, Bret R.

AU - Haverland, Nicole A.

AU - Mosley, R Lee

AU - Gendelman, Howard Eliot

PY - 2015/1/15

Y1 - 2015/1/15

N2 - Neurodegeneration after traumatic brain injury is facilitated by innate and adaptive immunity and can be harnessed to affect brain repair. In mice subjected to controlled cortical impact (CCI), we show that treatment with granulocyte macrophage colony stimulating factor (GM-CSF) affects regulatory T cell numbers in the cervical lymph nodes coincident with decreased lesion volumes and increased cortical tissue sparing. This paralleled increases in neurofilament and diminished reactive microglial staining. Transcriptomic analysis showed that GM-CSF induces robust immune neuroprotective responses seven days following CCI. Together, these results support the therapeutic potential of GM-CSF for TBI.

AB - Neurodegeneration after traumatic brain injury is facilitated by innate and adaptive immunity and can be harnessed to affect brain repair. In mice subjected to controlled cortical impact (CCI), we show that treatment with granulocyte macrophage colony stimulating factor (GM-CSF) affects regulatory T cell numbers in the cervical lymph nodes coincident with decreased lesion volumes and increased cortical tissue sparing. This paralleled increases in neurofilament and diminished reactive microglial staining. Transcriptomic analysis showed that GM-CSF induces robust immune neuroprotective responses seven days following CCI. Together, these results support the therapeutic potential of GM-CSF for TBI.

KW - Immunity

KW - Microglia

KW - Neuroinflammation

KW - T cell

KW - Traumatic brain injury

UR - http://www.scopus.com/inward/record.url?scp=84920999095&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920999095&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2014.11.002

DO - 10.1016/j.jneuroim.2014.11.002

M3 - Article

C2 - 25468272

AN - SCOPUS:84920999095

VL - 278

SP - 162

EP - 173

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

ER -