Grain sorghum whole kernel oil lowers plasma and liver cholesterol in male hamsters with minimal wax involvement

Bo Hyun Lee, Timothy P Carr, Curtis L. Weller, Susan Cuppett, Ismail M. Dweikat, Vicki L Schlegel

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The lipid fraction of the grain sorghum whole kernel (GS-WK) (i.e., phytosterol rich oil or policosanol rich wax) responsible for lowering cholesterol in hamsters fed the crude lipid (wax. +. oil) was determined. As expected, hamsters fed an atherogenic diet for a four week period presented with higher plasma non-HDL plasma and liver esterified cholesterol than those on the low fat diet. However, the atherogenic diet containing 5% (w/w) oil significantly lowered non-HDL plasma and liver cholesterol. Although the 5% wax supplement did not affect either plasma or liver cholesterol, excreted neutral sterol and bile acid were slightly higher than produced by the atherogenic diet. Still, cholesterol excretion negatively correlated with liver cholesterol concentration ( r= -0.681, p<. 0.001) across diets with the oil fraction producing the greatest impact. These combined results indicate that oil plays the most significant role in modulating cholesterol, most likely by inhibiting absorption, but subtle interactions by the wax may be involved. However, the sorghum oil would be the most potent component to serve as a possible heart health ingredient in functional foods.

Original languageEnglish (US)
Pages (from-to)709-718
Number of pages10
JournalJournal of Functional Foods
Volume7
Issue number1
DOIs
StatePublished - Jan 1 2014

Fingerprint

Sorghum
Waxes
grain sorghum
waxes
hamsters
Cricetinae
Oils
Cholesterol
cholesterol
oils
liver
Atherogenic Diet
Liver
seeds
policosanol
diet
Lipids
Phytosterols
Fat-Restricted Diet
Functional Food

Keywords

  • Cholesterol
  • Grain sorghum
  • Phytosterols
  • Policosanols
  • Whole kernels

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Grain sorghum whole kernel oil lowers plasma and liver cholesterol in male hamsters with minimal wax involvement. / Lee, Bo Hyun; Carr, Timothy P; Weller, Curtis L.; Cuppett, Susan; Dweikat, Ismail M.; Schlegel, Vicki L.

In: Journal of Functional Foods, Vol. 7, No. 1, 01.01.2014, p. 709-718.

Research output: Contribution to journalArticle

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