Graft-versus-host-like colitis associated with malignant thymoma

S. Kornacki, F. C. Hansen, Audrey J Lazenby

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

A case of a patient with a malignant thymoma who developed an unusual form of colitis is reported. The patient was a previously healthy 20-year-old man who was referred to the Johns Hopkins Medical Institution for biopsy and resection of a mediastinal mass, which proved to be a malignant thymoma. During this hospitalization and subsequently, the patient developed severe chronic diarrhea, the etiology of which remained uncertain after routine work-up, including cultures. Colonoscopic biopsies revealed only minimal inflammation but numerous, prominent apoptotic lesions within crypt epithelium, suggestive of an autoimmune or graft-versus-host-like colitis. The patient, who was immunocompetent and human immunodeficiency virus (HIV) negative, had no known risk factors for graft-versus-host-disease (e.g., no blood transfusions, no transplantation history before diarrheal episodes). Stool cultures for pathogenic bacteria and viruses were negative. The diarrhea and histologic findings eventually improved with steroid therapy yet returned on recurrence of the thymoma. This unusual form of colitis has not been previously reported to be associated with thymoma and is interesting in light of the role the thymus plays in immune regulation.

Original languageEnglish (US)
Pages (from-to)224-228
Number of pages5
JournalAmerican Journal of Surgical Pathology
Volume19
Issue number2
StatePublished - Jan 1 1995

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Thymoma
Colitis
Transplants
Diarrhea
Biopsy
Graft vs Host Disease
Blood Transfusion
Thymus Gland
Hospitalization
Epithelium
Transplantation
History
Steroids
HIV
Viruses
Inflammation
Bacteria
Recurrence
Therapeutics

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Graft-versus-host-like colitis associated with malignant thymoma. / Kornacki, S.; Hansen, F. C.; Lazenby, Audrey J.

In: American Journal of Surgical Pathology, Vol. 19, No. 2, 01.01.1995, p. 224-228.

Research output: Contribution to journalArticle

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