Gonococcal Infection: A Model of Molecular Pathogenesis

Bradley E. Britigan, Myron S. Cohen, P. Frederick Sparling

Research output: Contribution to journalReview article

77 Citations (Scopus)

Abstract

Human beings are the only reservoir for the gonococcus. In spite of public health efforts to control this pathogen, and the availability of adequate antibiotic therapy for 40 years, close to a million cases of gonococcal infection are reported in the United States annually.1 The increasing prevalence of antibiotic-resistant strains has complicated treatment regimens.2 3 4 5 Sequelae of gonococcal infection, including sterility and ectopic pregnancy, are serious health problems,6 particularly in less developed areas of the world. The gonococcus infects a diverse array of mucosal surfaces, including the urethra, endocervix, pharynx, conjunctiva, and rectum. In a minority of patients these infections progress.

Original languageEnglish (US)
Pages (from-to)1683-1694
Number of pages12
JournalNew England Journal of Medicine
Volume312
Issue number26
DOIs
StatePublished - Jun 27 1985
Externally publishedYes

Fingerprint

Molecular Models
Neisseria gonorrhoeae
Infection
Anti-Bacterial Agents
Ectopic Pregnancy
Conjunctiva
Urethra
Pharynx
Rectum
Infertility
Public Health
Health
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gonococcal Infection : A Model of Molecular Pathogenesis. / Britigan, Bradley E.; Cohen, Myron S.; Sparling, P. Frederick.

In: New England Journal of Medicine, Vol. 312, No. 26, 27.06.1985, p. 1683-1694.

Research output: Contribution to journalReview article

Britigan, Bradley E. ; Cohen, Myron S. ; Sparling, P. Frederick. / Gonococcal Infection : A Model of Molecular Pathogenesis. In: New England Journal of Medicine. 1985 ; Vol. 312, No. 26. pp. 1683-1694.
@article{b58ba97ceb064183b6304d5e21199f9c,
title = "Gonococcal Infection: A Model of Molecular Pathogenesis",
abstract = "Human beings are the only reservoir for the gonococcus. In spite of public health efforts to control this pathogen, and the availability of adequate antibiotic therapy for 40 years, close to a million cases of gonococcal infection are reported in the United States annually.1 The increasing prevalence of antibiotic-resistant strains has complicated treatment regimens.2 3 4 5 Sequelae of gonococcal infection, including sterility and ectopic pregnancy, are serious health problems,6 particularly in less developed areas of the world. The gonococcus infects a diverse array of mucosal surfaces, including the urethra, endocervix, pharynx, conjunctiva, and rectum. In a minority of patients these infections progress.",
author = "Britigan, {Bradley E.} and Cohen, {Myron S.} and Sparling, {P. Frederick}",
year = "1985",
month = "6",
day = "27",
doi = "10.1056/NEJM198506273122606",
language = "English (US)",
volume = "312",
pages = "1683--1694",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
number = "26",

}

TY - JOUR

T1 - Gonococcal Infection

T2 - A Model of Molecular Pathogenesis

AU - Britigan, Bradley E.

AU - Cohen, Myron S.

AU - Sparling, P. Frederick

PY - 1985/6/27

Y1 - 1985/6/27

N2 - Human beings are the only reservoir for the gonococcus. In spite of public health efforts to control this pathogen, and the availability of adequate antibiotic therapy for 40 years, close to a million cases of gonococcal infection are reported in the United States annually.1 The increasing prevalence of antibiotic-resistant strains has complicated treatment regimens.2 3 4 5 Sequelae of gonococcal infection, including sterility and ectopic pregnancy, are serious health problems,6 particularly in less developed areas of the world. The gonococcus infects a diverse array of mucosal surfaces, including the urethra, endocervix, pharynx, conjunctiva, and rectum. In a minority of patients these infections progress.

AB - Human beings are the only reservoir for the gonococcus. In spite of public health efforts to control this pathogen, and the availability of adequate antibiotic therapy for 40 years, close to a million cases of gonococcal infection are reported in the United States annually.1 The increasing prevalence of antibiotic-resistant strains has complicated treatment regimens.2 3 4 5 Sequelae of gonococcal infection, including sterility and ectopic pregnancy, are serious health problems,6 particularly in less developed areas of the world. The gonococcus infects a diverse array of mucosal surfaces, including the urethra, endocervix, pharynx, conjunctiva, and rectum. In a minority of patients these infections progress.

UR - http://www.scopus.com/inward/record.url?scp=0022253699&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022253699&partnerID=8YFLogxK

U2 - 10.1056/NEJM198506273122606

DO - 10.1056/NEJM198506273122606

M3 - Review article

C2 - 2860565

AN - SCOPUS:0022253699

VL - 312

SP - 1683

EP - 1694

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 26

ER -