Golgi organization and the apical extension of fungal hyphae: An essential relationship

Steven D. Harris

Research output: Contribution to journalComment/debate

8 Citations (Scopus)

Abstract

The Golgi apparatus performs crucial functions in the sorting and processing of proteins destined for secretion from eukaryotic cells. In filamentous fungi, organization of the Golgi apparatus reflects the unique challenges brought about by the highly polarized nature of hyphal growth. Recent results show that Golgi compartments are spatially segregated within hyphal tip cells in a manner that depends upon the integrity of the cytoskeleton. Moreover, loss of normal Golgi organization stops polarized hyphal extension and triggers de-polarization of the hyphal tip. These results emphasize the point that a spatially organized and dynamic Golgi apparatus represents an adaptation that is as important for hyphal extension as is the presence of a Spitzenkörper. In addition, they also identify regulatory mechanisms that could enable controlled de-polarization of hyphae during development or infection-related morphogenesis.

Original languageEnglish (US)
Pages (from-to)212-215
Number of pages4
JournalMolecular Microbiology
Volume89
Issue number2
DOIs
StatePublished - Jul 1 2013

Fingerprint

Hyphae
Golgi Apparatus
Eukaryotic Cells
Protein Transport
Cytoskeleton
Morphogenesis
Fungi
Growth
Infection

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Cite this

Golgi organization and the apical extension of fungal hyphae : An essential relationship. / Harris, Steven D.

In: Molecular Microbiology, Vol. 89, No. 2, 01.07.2013, p. 212-215.

Research output: Contribution to journalComment/debate

@article{57a923f9050b47c89beb8e846702727a,
title = "Golgi organization and the apical extension of fungal hyphae: An essential relationship",
abstract = "The Golgi apparatus performs crucial functions in the sorting and processing of proteins destined for secretion from eukaryotic cells. In filamentous fungi, organization of the Golgi apparatus reflects the unique challenges brought about by the highly polarized nature of hyphal growth. Recent results show that Golgi compartments are spatially segregated within hyphal tip cells in a manner that depends upon the integrity of the cytoskeleton. Moreover, loss of normal Golgi organization stops polarized hyphal extension and triggers de-polarization of the hyphal tip. These results emphasize the point that a spatially organized and dynamic Golgi apparatus represents an adaptation that is as important for hyphal extension as is the presence of a Spitzenk{\"o}rper. In addition, they also identify regulatory mechanisms that could enable controlled de-polarization of hyphae during development or infection-related morphogenesis.",
author = "Harris, {Steven D.}",
year = "2013",
month = "7",
day = "1",
doi = "10.1111/mmi.12291",
language = "English (US)",
volume = "89",
pages = "212--215",
journal = "Molecular Microbiology",
issn = "0950-382X",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Golgi organization and the apical extension of fungal hyphae

T2 - An essential relationship

AU - Harris, Steven D.

PY - 2013/7/1

Y1 - 2013/7/1

N2 - The Golgi apparatus performs crucial functions in the sorting and processing of proteins destined for secretion from eukaryotic cells. In filamentous fungi, organization of the Golgi apparatus reflects the unique challenges brought about by the highly polarized nature of hyphal growth. Recent results show that Golgi compartments are spatially segregated within hyphal tip cells in a manner that depends upon the integrity of the cytoskeleton. Moreover, loss of normal Golgi organization stops polarized hyphal extension and triggers de-polarization of the hyphal tip. These results emphasize the point that a spatially organized and dynamic Golgi apparatus represents an adaptation that is as important for hyphal extension as is the presence of a Spitzenkörper. In addition, they also identify regulatory mechanisms that could enable controlled de-polarization of hyphae during development or infection-related morphogenesis.

AB - The Golgi apparatus performs crucial functions in the sorting and processing of proteins destined for secretion from eukaryotic cells. In filamentous fungi, organization of the Golgi apparatus reflects the unique challenges brought about by the highly polarized nature of hyphal growth. Recent results show that Golgi compartments are spatially segregated within hyphal tip cells in a manner that depends upon the integrity of the cytoskeleton. Moreover, loss of normal Golgi organization stops polarized hyphal extension and triggers de-polarization of the hyphal tip. These results emphasize the point that a spatially organized and dynamic Golgi apparatus represents an adaptation that is as important for hyphal extension as is the presence of a Spitzenkörper. In addition, they also identify regulatory mechanisms that could enable controlled de-polarization of hyphae during development or infection-related morphogenesis.

UR - http://www.scopus.com/inward/record.url?scp=84880134503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880134503&partnerID=8YFLogxK

U2 - 10.1111/mmi.12291

DO - 10.1111/mmi.12291

M3 - Comment/debate

C2 - 23750923

AN - SCOPUS:84880134503

VL - 89

SP - 212

EP - 215

JO - Molecular Microbiology

JF - Molecular Microbiology

SN - 0950-382X

IS - 2

ER -