GM-CSF induces neuroprotective and anti-inflammatory responses in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxicated mice

Lisa M. Kosloski, Elizabeth A. Kosmacek, Katherine E. Olson, R Lee Mosley, Howard Eliot Gendelman

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Innate and adaptive immune responses can speed nigrostriatal neurodegeneration in Parkinson's disease (PD). We posit that GM-CSF can attenuate such responses. In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxicated mice, GM-CSF given prior to MPTP protected nigral dopaminergic neurons coincident with altered microglial morphologies and regulatory T cell (Treg) induction. Adoptive transfer of GM-CSF-induced Treg to MPTP mice protected nigral neurons. Gene expression analyses revealed novel immune-based neuronal protection pathways linked to the upregulation of IL-27. The results provide evidence that GM-CSF modulation of immunity could be of clinical benefit for PD.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalJournal of Neuroimmunology
Volume265
Issue number1-2
DOIs
StatePublished - Dec 15 2013

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Granulocyte-Macrophage Colony-Stimulating Factor
Anti-Inflammatory Agents
Substantia Nigra
Parkinson Disease
Interleukin-27
Adoptive Transfer
Dopaminergic Neurons
Adaptive Immunity
Regulatory T-Lymphocytes
Innate Immunity
Immunity
Up-Regulation
Gene Expression
Neurons
4-phenyl-1,2,3,6-tetrahydropyridine

Keywords

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Innate immunity
  • Neuroinflammation
  • Neuroprotection
  • Parkinson's disease
  • Regulatory T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

GM-CSF induces neuroprotective and anti-inflammatory responses in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxicated mice. / Kosloski, Lisa M.; Kosmacek, Elizabeth A.; Olson, Katherine E.; Mosley, R Lee; Gendelman, Howard Eliot.

In: Journal of Neuroimmunology, Vol. 265, No. 1-2, 15.12.2013, p. 1-10.

Research output: Contribution to journalArticle

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AU - Gendelman, Howard Eliot

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