Glycosyltransferases encoded by viruses

Nicolas Markine-Goriaynoff, Laurent Gillet, James L. Van Etten, Haralambos Korres, Naresh Verma, Alain Vanderplasschen

Research output: Contribution to journalReview article

63 Citations (Scopus)

Abstract

Studies of cellular biology in recent decades have highlighted the crucial roles of glycans in numerous important biological processes, raising the concept of glycomics that is now considered as important as genomics, transcriptomics and proteomics. For millions of years, viruses have been co-evolving with their hosts. Consequently, during this co-evolution process, viruses have acquired mechanisms to mimic, hijack or sabotage host processes that favour their replication, including mechanisms to modify the glycome. The importance of the glycome in the regulation of host-virus interactions has recently led to a new concept called 'glycovirology'. One fascinating aspect of glycovirology is the study of how viruses affect the glycome. Viruses reach that goal either by regulating expression of host glycosyltransferases or by expressing their own glycosyltransferases. This review describes all virally encoded glycosyltransferases and discusses their established or putative functions. The description of these enzymes illustrates several intriguing aspects of virology and provides further support for the importance of glycomics in biological processes.

Original languageEnglish (US)
Pages (from-to)2741-2754
Number of pages14
JournalJournal of General Virology
Volume85
Issue number10
DOIs
StatePublished - Oct 1 2004

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Glycosyltransferases
Viruses
Glycomics
Biological Phenomena
Virology
Genomics
Proteomics
Polysaccharides
Cell Biology
Enzymes

ASJC Scopus subject areas

  • Virology

Cite this

Markine-Goriaynoff, N., Gillet, L., Van Etten, J. L., Korres, H., Verma, N., & Vanderplasschen, A. (2004). Glycosyltransferases encoded by viruses. Journal of General Virology, 85(10), 2741-2754. https://doi.org/10.1099/vir.0.80320-0

Glycosyltransferases encoded by viruses. / Markine-Goriaynoff, Nicolas; Gillet, Laurent; Van Etten, James L.; Korres, Haralambos; Verma, Naresh; Vanderplasschen, Alain.

In: Journal of General Virology, Vol. 85, No. 10, 01.10.2004, p. 2741-2754.

Research output: Contribution to journalReview article

Markine-Goriaynoff, N, Gillet, L, Van Etten, JL, Korres, H, Verma, N & Vanderplasschen, A 2004, 'Glycosyltransferases encoded by viruses', Journal of General Virology, vol. 85, no. 10, pp. 2741-2754. https://doi.org/10.1099/vir.0.80320-0
Markine-Goriaynoff N, Gillet L, Van Etten JL, Korres H, Verma N, Vanderplasschen A. Glycosyltransferases encoded by viruses. Journal of General Virology. 2004 Oct 1;85(10):2741-2754. https://doi.org/10.1099/vir.0.80320-0
Markine-Goriaynoff, Nicolas ; Gillet, Laurent ; Van Etten, James L. ; Korres, Haralambos ; Verma, Naresh ; Vanderplasschen, Alain. / Glycosyltransferases encoded by viruses. In: Journal of General Virology. 2004 ; Vol. 85, No. 10. pp. 2741-2754.
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