24 Citations (Scopus)

Abstract

Background: The Golgi docking mechanisms for transport vesicles carrying glycosyltransferases are largely unknown. Results: C1GalT1 utilizes GM130-GRASP65 when GRASP65 is available but GM130-Giantin without GRASP65, whereas C2GnT-M employs Giantin for Golgi targeting. Conclusion: The Golgi-targeting mechanism is glycosyltransferase-specific. Significance: Understanding the Golgi-targeting mechanisms of glycosyltransferases may help uncover altered glycosylation in some diseases.

Original languageEnglish (US)
Pages (from-to)37621-37627
Number of pages7
JournalJournal of Biological Chemistry
Volume287
Issue number45
DOIs
StatePublished - Nov 2 2012

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Glycosyltransferases
Glycosylation
Transport Vesicles
macrogolgin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Glycosyltransferase-specific Golgi-targeting mechanisms. / Petrosyan, Armen; Ali, Mohamed F.; Cheng, Pi-Wan.

In: Journal of Biological Chemistry, Vol. 287, No. 45, 02.11.2012, p. 37621-37627.

Research output: Contribution to journalArticle

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AU - Cheng, Pi-Wan

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