Glycoproteomic Profiling Provides Candidate Myocardial Infarction Predictors of Later Progression to Heart Failure

Kristine Y. Deleon-Pennell, Osasere K. Ero, Yonggang Ma, Rugmani Padmanabhan Iyer, Elizabeth R. Flynn, Ingrid Espinoza, Solomon K. Musani, Ramachandran S. Vasan, Michael E. Hall, Ervin R. Fox, Merry L. Lindsey

Research output: Contribution to journalArticle

Abstract

We hypothesized that identifying plasma glycoproteins that predict the development of heart failure following myocardial infarction (MI) could help to stratify subjects at risk. Plasma collected at visit 2 (2005-2008) from an MI subset of Jackson Heart Study participants underwent glycoproteomics and was grouped by the outcome: (1) heart failure hospitalization after visit 2 (n = 15) and (2) without hospitalization by 2012 (n = 45). Proteins were mapped for biological processes and functional pathways using Ingenuity Pathway Analysis and linked to clinical characteristics. A total of 198 glycopeptides corresponding to 88 proteins were identified (data available via ProteomeXchange with identifier PXD009870). Of these, 14 glycopeptides were significantly different between MI and MI + HF groups and corresponded to apolipoprotein (Apo) F, transthyretin, Apo C-IV, prostaglandin-D2 synthase, complement C9, and CD59 (p < 0.05 for all). All proteins were elevated in the MI + HF group, except CD59, which was lower. Four canonical pathways were upregulated in the MI + HF group (p < 0.05 for all): acute phase response, liver X receptor/retinoid X receptor, and macrophage reactive oxygen species generation. The coagulation pathway was significantly downregulated in the MI + HF group (p < 0.05). Even after adjustment for age and sex, Apo F was associated with the increased risk for heart failure (OR = 21.84; 95% CI 3.20-149.14). In conclusion, glycoproteomic profiling provided candidate early MI predictors of later progression to heart failure.

Original languageEnglish (US)
Pages (from-to)1272-1280
Number of pages9
JournalACS Omega
Volume4
Issue number1
DOIs
StatePublished - Jan 15 2019

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Glycopeptides
prostaglandin R2 D-isomerase
Proteins
Complement C9
Apolipoproteins C
Retinoid X Receptors
Plasmas
Glycoproteins
Prealbumin
Macrophages
Coagulation
Liver
Reactive Oxygen Species
Oxygen
Apolipoproteins
apolipoprotein F
Prostaglandin-Endoperoxide Synthases

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Glycoproteomic Profiling Provides Candidate Myocardial Infarction Predictors of Later Progression to Heart Failure. / Deleon-Pennell, Kristine Y.; Ero, Osasere K.; Ma, Yonggang; Padmanabhan Iyer, Rugmani; Flynn, Elizabeth R.; Espinoza, Ingrid; Musani, Solomon K.; Vasan, Ramachandran S.; Hall, Michael E.; Fox, Ervin R.; Lindsey, Merry L.

In: ACS Omega, Vol. 4, No. 1, 15.01.2019, p. 1272-1280.

Research output: Contribution to journalArticle

Deleon-Pennell, KY, Ero, OK, Ma, Y, Padmanabhan Iyer, R, Flynn, ER, Espinoza, I, Musani, SK, Vasan, RS, Hall, ME, Fox, ER & Lindsey, ML 2019, 'Glycoproteomic Profiling Provides Candidate Myocardial Infarction Predictors of Later Progression to Heart Failure', ACS Omega, vol. 4, no. 1, pp. 1272-1280. https://doi.org/10.1021/acsomega.8b02207
Deleon-Pennell KY, Ero OK, Ma Y, Padmanabhan Iyer R, Flynn ER, Espinoza I et al. Glycoproteomic Profiling Provides Candidate Myocardial Infarction Predictors of Later Progression to Heart Failure. ACS Omega. 2019 Jan 15;4(1):1272-1280. https://doi.org/10.1021/acsomega.8b02207
Deleon-Pennell, Kristine Y. ; Ero, Osasere K. ; Ma, Yonggang ; Padmanabhan Iyer, Rugmani ; Flynn, Elizabeth R. ; Espinoza, Ingrid ; Musani, Solomon K. ; Vasan, Ramachandran S. ; Hall, Michael E. ; Fox, Ervin R. ; Lindsey, Merry L. / Glycoproteomic Profiling Provides Candidate Myocardial Infarction Predictors of Later Progression to Heart Failure. In: ACS Omega. 2019 ; Vol. 4, No. 1. pp. 1272-1280.
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abstract = "We hypothesized that identifying plasma glycoproteins that predict the development of heart failure following myocardial infarction (MI) could help to stratify subjects at risk. Plasma collected at visit 2 (2005-2008) from an MI subset of Jackson Heart Study participants underwent glycoproteomics and was grouped by the outcome: (1) heart failure hospitalization after visit 2 (n = 15) and (2) without hospitalization by 2012 (n = 45). Proteins were mapped for biological processes and functional pathways using Ingenuity Pathway Analysis and linked to clinical characteristics. A total of 198 glycopeptides corresponding to 88 proteins were identified (data available via ProteomeXchange with identifier PXD009870). Of these, 14 glycopeptides were significantly different between MI and MI + HF groups and corresponded to apolipoprotein (Apo) F, transthyretin, Apo C-IV, prostaglandin-D2 synthase, complement C9, and CD59 (p < 0.05 for all). All proteins were elevated in the MI + HF group, except CD59, which was lower. Four canonical pathways were upregulated in the MI + HF group (p < 0.05 for all): acute phase response, liver X receptor/retinoid X receptor, and macrophage reactive oxygen species generation. The coagulation pathway was significantly downregulated in the MI + HF group (p < 0.05). Even after adjustment for age and sex, Apo F was associated with the increased risk for heart failure (OR = 21.84; 95{\%} CI 3.20-149.14). In conclusion, glycoproteomic profiling provided candidate early MI predictors of later progression to heart failure.",
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AU - Padmanabhan Iyer, Rugmani

AU - Flynn, Elizabeth R.

AU - Espinoza, Ingrid

AU - Musani, Solomon K.

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AU - Fox, Ervin R.

AU - Lindsey, Merry L.

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