Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by N-methyl-d-aspartate receptor activation

Elizabeth Palmer, Daniel T Monaghan, Carl W. Cotman

Research output: Contribution to journalArticle

Abstract

Excitatory amino acid receptors in the neonatal rat hippocampus have opposing actions on phosphoinositide (PI) metabolism. Quisqualic acid (QA), but not the QA receptor agonist AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid), potently stimulates inositol phosphate (IP) formation. Activation of NMDA (N-methyl-d-aspartate) receptors inhibits the QA-induced stimulation by 70% by a mechanism which is dependent on extracellular calcium.

Original languageEnglish (US)
Pages (from-to)161-165
Number of pages5
JournalMolecular Brain Research
Volume4
Issue number2
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Quisqualic Acid
AMPA Receptors
Glutamate Receptors
Phosphatidylinositols
Inositol Phosphates
Hippocampus
Calcium
aspartic acid receptor

Keywords

  • 6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline
  • Calcium
  • Glutamate receptor
  • Hippocampus
  • N-Methyl-d-aspartic acid
  • Phosphoinositide metabolism
  • Quisqualic acid
  • α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

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title = "Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by N-methyl-d-aspartate receptor activation",
abstract = "Excitatory amino acid receptors in the neonatal rat hippocampus have opposing actions on phosphoinositide (PI) metabolism. Quisqualic acid (QA), but not the QA receptor agonist AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid), potently stimulates inositol phosphate (IP) formation. Activation of NMDA (N-methyl-d-aspartate) receptors inhibits the QA-induced stimulation by 70{\%} by a mechanism which is dependent on extracellular calcium.",
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T2 - stimulation via quisqualate receptors is inhibited by N-methyl-d-aspartate receptor activation

AU - Palmer, Elizabeth

AU - Monaghan, Daniel T

AU - Cotman, Carl W.

PY - 1988

Y1 - 1988

N2 - Excitatory amino acid receptors in the neonatal rat hippocampus have opposing actions on phosphoinositide (PI) metabolism. Quisqualic acid (QA), but not the QA receptor agonist AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid), potently stimulates inositol phosphate (IP) formation. Activation of NMDA (N-methyl-d-aspartate) receptors inhibits the QA-induced stimulation by 70% by a mechanism which is dependent on extracellular calcium.

AB - Excitatory amino acid receptors in the neonatal rat hippocampus have opposing actions on phosphoinositide (PI) metabolism. Quisqualic acid (QA), but not the QA receptor agonist AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid), potently stimulates inositol phosphate (IP) formation. Activation of NMDA (N-methyl-d-aspartate) receptors inhibits the QA-induced stimulation by 70% by a mechanism which is dependent on extracellular calcium.

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