Glucose and Lactate Oxidation Rates in the Fetal Lamb

William W. Hay, Stephen A. Myers, John W. Sparks, Randall B. Wilkening, Giacomo Meschia, Frederick C. Battaglia

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Both glucose and lactate are nutrients of the ovine fetus. Each may be used by the fetus as a fuel for oxidation or as a source of carbon for energy storage and net tissue accretion. The present report describes the oxidation rates of glucose and lactate in vivo for the fetal lamb over a relatively short time period. The fraction of fetal glucose or lactate oxidized was defined as the ratio of 14CO2 excretion across the umbilical circulation to the net entry of [14C]glucose or [14C]lactate into fetal tissues. The fraction of glucose oxidized over a 3-hr study averaged 61.2%, accounting for 2.55 mg · min-1 · kg-1 of glucose oxidized and for 28% of the simultaneous net oxygen uptake. The fraction of lactate oxidized averaged 71.5%, accounting for 4.12 mg·min-1 · kg-1 of lactate oxidized. Oxidation fractions and rates for both glucose and lactate increased with their concentrations in fetal blood suggesting sparing of other fuels for oxidation at higher glucose and lactate concentrations.

Original languageEnglish (US)
Pages (from-to)553-563
Number of pages11
JournalProceedings of the Society for Experimental Biology and Medicine
Volume173
Issue number4
DOIs
StatePublished - Sep 1983

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Lactic Acid
Glucose
Oxidation
Fetus
Tissue
Umbilicus
Fetal Blood
Energy storage
Nutrients
Sheep
Blood
Carbon
Oxygen
Food

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Glucose and Lactate Oxidation Rates in the Fetal Lamb. / Hay, William W.; Myers, Stephen A.; Sparks, John W.; Wilkening, Randall B.; Meschia, Giacomo; Battaglia, Frederick C.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 173, No. 4, 09.1983, p. 553-563.

Research output: Contribution to journalArticle

Hay, William W. ; Myers, Stephen A. ; Sparks, John W. ; Wilkening, Randall B. ; Meschia, Giacomo ; Battaglia, Frederick C. / Glucose and Lactate Oxidation Rates in the Fetal Lamb. In: Proceedings of the Society for Experimental Biology and Medicine. 1983 ; Vol. 173, No. 4. pp. 553-563.
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