Gluconeogenesis in the newborn

Satish C. Kalhan, Zahi Zeidan

Research output: Contribution to journalArticle

Abstract

Gluconeogenesis, the formation of glucose from non-glucose carbon precursors, is expressed for the first time in most mammalian species immediately after birth. The appearance of gluconeogenesis, along with the contribution of glycogenolysis, is responsible for the maintenance of a steady rate of glucose production. The recent development of novel tracer isotopic methods have allowed precise quantification of the contribution of gluconeogenesis to glucose production in newborn infants and adults. These data show that gluconeogenesis is active both during fasting and during the fed state. In the healthy human newborn following a brief fast, gluconeogenesis via pyruvate contributes -30% to total glucose production.

Original languageEnglish (US)
Pages (from-to)245-255
Number of pages11
JournalPerinatology
Volume4
Issue number5
StatePublished - Sep 1 2002

Fingerprint

Gluconeogenesis
Newborn Infant
Glucose
Glycogenolysis
Pyruvic Acid
Fasting
Carbon
Maintenance
Parturition

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Kalhan, S. C., & Zeidan, Z. (2002). Gluconeogenesis in the newborn. Perinatology, 4(5), 245-255.

Gluconeogenesis in the newborn. / Kalhan, Satish C.; Zeidan, Zahi.

In: Perinatology, Vol. 4, No. 5, 01.09.2002, p. 245-255.

Research output: Contribution to journalArticle

Kalhan, SC & Zeidan, Z 2002, 'Gluconeogenesis in the newborn', Perinatology, vol. 4, no. 5, pp. 245-255.
Kalhan SC, Zeidan Z. Gluconeogenesis in the newborn. Perinatology. 2002 Sep 1;4(5):245-255.
Kalhan, Satish C. ; Zeidan, Zahi. / Gluconeogenesis in the newborn. In: Perinatology. 2002 ; Vol. 4, No. 5. pp. 245-255.
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