Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis

Bart J. Crielaard, Cristianne J.F. Rijcken, Lingdong Quan, Steffen Van Der Wal, Isil Altintas, Martin Van Der Pot, John A.W. Kruijtzer, Rob M.J. Liskamp, Raymond M. Schiffelers, Cornelus F. Van Nostrum, Wim E. Hennink, Dong Wang, Twan Lammers, Gert Storm

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Polymerizable and hydrolytically cleavable dexamethasone (DEX, red dot in picture) derivatives were covalently entrapped in core-cross-linked polymeric micelles that were prepared from a thermosensitive block copolymer (yellow and gray building block). By varying the oxidation degree of the thioether in the drug linker, the release rate of DEX could be controlled. The DEX-loaded micelles were used for efficient treatment of inflammatory arthritis in two animal models.

Original languageEnglish (US)
Pages (from-to)7254-7258
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number29
DOIs
StatePublished - Jul 16 2012

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Keywords

  • Drug delivery
  • Glucocorticoids
  • Micelles
  • Nanomedicine
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Crielaard, B. J., Rijcken, C. J. F., Quan, L., Van Der Wal, S., Altintas, I., Van Der Pot, M., Kruijtzer, J. A. W., Liskamp, R. M. J., Schiffelers, R. M., Van Nostrum, C. F., Hennink, W. E., Wang, D., Lammers, T., & Storm, G. (2012). Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. Angewandte Chemie - International Edition, 51(29), 7254-7258. https://doi.org/10.1002/anie.201202713