Global trends in esophageal cancer

Gautam K. Malhotra, Ujwal Yanala, Advaitaa Ravipati, Matthew Follet, M. Vijayakumar, Chandrakanth Are

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

BACKGROUND AND OBJECTIVES: Esophageal Cancer (EC) is a lethal malignancy with poor prognosis and significant variations in the incidence, mortality, and histopathology based on geographic regions. The aim of this study was to quantitatively analyze these variations to identify patterns and areas for further research. METHODS: We utilized the GLOBOCAN 2012, and Cancer Incidence in five Continents, Volume X (CI5X) database to analyze variations in EC incidence and mortality. RESULTS: We found the EC incidence and mortality is geographically varied with a particularly high burden in East Asia and Eastern/Southern Africa where esophageal squamous cell carcinoma (SCC) predominates over adenocarcinoma (AC). Interestingly, there is a dichotomy between the high incidence of esophageal SCC in East Africa and low incidence in West Africa. The global incidence and mortality from EC is expected to rise in the coming decades. Asia, and China in particular, will continue to be the areas most burdened by EC, while Africa is expected to surpass the incidence and mortality rates of Europe. CONCLUSIONS: The global burden of EC is expected to rise in the coming years. Understanding the geographic, environmental, and genetic contributors to the development of EC will be essential in combating its prevalence.

Original languageEnglish (US)
Pages (from-to)564-579
Number of pages16
JournalJournal of Surgical Oncology
Volume115
Issue number5
DOIs
StatePublished - Apr 1 2017

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Esophageal Neoplasms
Incidence
Mortality
Eastern Africa
Southern Africa
Western Africa
Far East
China
Neoplasms
Adenocarcinoma
Databases
Research

Keywords

  • Asia
  • East Africa
  • adenocarcinoma
  • esophageal cancer
  • squamous cell carcinoma

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Malhotra, G. K., Yanala, U., Ravipati, A., Follet, M., Vijayakumar, M., & Are, C. (2017). Global trends in esophageal cancer. Journal of Surgical Oncology, 115(5), 564-579. https://doi.org/10.1002/jso.24592

Global trends in esophageal cancer. / Malhotra, Gautam K.; Yanala, Ujwal; Ravipati, Advaitaa; Follet, Matthew; Vijayakumar, M.; Are, Chandrakanth.

In: Journal of Surgical Oncology, Vol. 115, No. 5, 01.04.2017, p. 564-579.

Research output: Contribution to journalArticle

Malhotra, GK, Yanala, U, Ravipati, A, Follet, M, Vijayakumar, M & Are, C 2017, 'Global trends in esophageal cancer', Journal of Surgical Oncology, vol. 115, no. 5, pp. 564-579. https://doi.org/10.1002/jso.24592
Malhotra GK, Yanala U, Ravipati A, Follet M, Vijayakumar M, Are C. Global trends in esophageal cancer. Journal of Surgical Oncology. 2017 Apr 1;115(5):564-579. https://doi.org/10.1002/jso.24592
Malhotra, Gautam K. ; Yanala, Ujwal ; Ravipati, Advaitaa ; Follet, Matthew ; Vijayakumar, M. ; Are, Chandrakanth. / Global trends in esophageal cancer. In: Journal of Surgical Oncology. 2017 ; Vol. 115, No. 5. pp. 564-579.
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