Gingival fluid IL‐1β and IL‐6 levels in menopause

Richard A Reinhardt, M. P. Masada, Jeffrey B Payne, A. C. Allison, L. M. DuBois

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Abstract Menopause and oophorectomy without estrogen therapy (ED) have been associated with increased production of bone‐active cytokines by peripheral blood mononuclear cells. The current study extended evaluation to gingival crevicular fluid (GCF) levels of interleukin (IL)‐1β and IL–6 in such subjects compared to premenopausal and postmenopausal estrogen‐treated females (ES). 13 ED and 13 ES Caucasians with a history of moderate‐severe adult periodontitis provided GCF from 1–3 clinically identical sites each (5–6 mm probing depth, 5–7 mm clinical attachment loss, bleeding on probing). 30 s GCF samples were obtained and evaluated for IL‐1β and IL‐6 levels using two‐site enzyme‐linked immunosorbent assays (ELISAs). The frequency of GCF IL‐1β‐positive subjects was elevated in ED versus ES (92% versus 23%; p < 0.0004, X2; analysis). IL‐6 was detected more frequently in ED subjects (23% versus 8%; not significant); however, the frequency of IL‐6 detection was low in both groups due to short sampling times. These data support the concept that clinical conditions causing low estrogen environments allow increased local production of the bone‐active cytokine IL‐β, and perhaps IL‐6.

Original languageEnglish (US)
Pages (from-to)22-25
Number of pages4
JournalJournal of Clinical Periodontology
Volume21
Issue number1
DOIs
StatePublished - Jan 1994

Fingerprint

Gingival Crevicular Fluid
Menopause
Interleukin-6
Estrogens
Cytokines
Chronic Periodontitis
Immunosorbents
Interleukins
Ovariectomy
Interleukin-1
Blood Cells
Hemorrhage

Keywords

  • estrogen
  • interleukin (1L)‐1β
  • interleukin (ILJ‐6
  • menopause
  • periodontitis

ASJC Scopus subject areas

  • Periodontics

Cite this

Gingival fluid IL‐1β and IL‐6 levels in menopause. / Reinhardt, Richard A; Masada, M. P.; Payne, Jeffrey B; Allison, A. C.; DuBois, L. M.

In: Journal of Clinical Periodontology, Vol. 21, No. 1, 01.1994, p. 22-25.

Research output: Contribution to journalArticle

Reinhardt, Richard A ; Masada, M. P. ; Payne, Jeffrey B ; Allison, A. C. ; DuBois, L. M. / Gingival fluid IL‐1β and IL‐6 levels in menopause. In: Journal of Clinical Periodontology. 1994 ; Vol. 21, No. 1. pp. 22-25.
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