Gestational cortisol and social play shape development of marmosets' HPA functioning and behavioral responses to stressors

Aaryn C. Mustoe, Jack H. Taylor, Andrew K. Birnie, Michelle C. Huffman, Jeffrey A French

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Both gestational cortisol exposure (GCE) and variability in postnatal environments can shape the later-life behavioral and endocrine outcomes of the hypothalamic-pituitary-adrenal (HPA) axis. We examined the influence of GCE and social play on HPA functioning in developing marmosets. Maternal urinary cortisol samples were collected across pregnancy to determine GCE for 28 marmoset offspring (19 litters). We administered a social separation stressor to offspring at 6, 12, and 18 months of age, during which we collected urinary cortisol samples and behavioral observations. Increased GCE was associated with increased basal cortisol levels and cortisol reactivity, but the strength of this relationship decreased across age. Increased social play was associated with decreased basal cortisol levels and a marginally greater reduction in cortisol reactivity as offspring aged, regardless of offspring GCE. Thus, GCE is associated with HPA functioning, but socially enriching postnatal environments can alter the effects associated with increased fetal exposure to glucocorticoids.

Original languageEnglish (US)
Pages (from-to)1229-1243
Number of pages15
JournalDevelopmental Psychobiology
Volume56
Issue number6
DOIs
StatePublished - Jan 1 2014

Fingerprint

Callithrix
Hydrocortisone
Glucocorticoids

Keywords

  • Cortisol reactivity
  • Development
  • Fetal programming
  • HPA axis
  • Marmoset
  • Non-human primate
  • Prenatal cortisol
  • Social play

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Developmental Neuroscience
  • Developmental Biology
  • Behavioral Neuroscience

Cite this

Gestational cortisol and social play shape development of marmosets' HPA functioning and behavioral responses to stressors. / Mustoe, Aaryn C.; Taylor, Jack H.; Birnie, Andrew K.; Huffman, Michelle C.; French, Jeffrey A.

In: Developmental Psychobiology, Vol. 56, No. 6, 01.01.2014, p. 1229-1243.

Research output: Contribution to journalArticle

Mustoe, Aaryn C. ; Taylor, Jack H. ; Birnie, Andrew K. ; Huffman, Michelle C. ; French, Jeffrey A. / Gestational cortisol and social play shape development of marmosets' HPA functioning and behavioral responses to stressors. In: Developmental Psychobiology. 2014 ; Vol. 56, No. 6. pp. 1229-1243.
@article{7c35477973cf47409593ca4985a0f15d,
title = "Gestational cortisol and social play shape development of marmosets' HPA functioning and behavioral responses to stressors",
abstract = "Both gestational cortisol exposure (GCE) and variability in postnatal environments can shape the later-life behavioral and endocrine outcomes of the hypothalamic-pituitary-adrenal (HPA) axis. We examined the influence of GCE and social play on HPA functioning in developing marmosets. Maternal urinary cortisol samples were collected across pregnancy to determine GCE for 28 marmoset offspring (19 litters). We administered a social separation stressor to offspring at 6, 12, and 18 months of age, during which we collected urinary cortisol samples and behavioral observations. Increased GCE was associated with increased basal cortisol levels and cortisol reactivity, but the strength of this relationship decreased across age. Increased social play was associated with decreased basal cortisol levels and a marginally greater reduction in cortisol reactivity as offspring aged, regardless of offspring GCE. Thus, GCE is associated with HPA functioning, but socially enriching postnatal environments can alter the effects associated with increased fetal exposure to glucocorticoids.",
keywords = "Cortisol reactivity, Development, Fetal programming, HPA axis, Marmoset, Non-human primate, Prenatal cortisol, Social play",
author = "Mustoe, {Aaryn C.} and Taylor, {Jack H.} and Birnie, {Andrew K.} and Huffman, {Michelle C.} and French, {Jeffrey A}",
year = "2014",
month = "1",
day = "1",
doi = "10.1002/dev.21203",
language = "English (US)",
volume = "56",
pages = "1229--1243",
journal = "Developmental Psychobiology",
issn = "0012-1630",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - Gestational cortisol and social play shape development of marmosets' HPA functioning and behavioral responses to stressors

AU - Mustoe, Aaryn C.

AU - Taylor, Jack H.

AU - Birnie, Andrew K.

AU - Huffman, Michelle C.

AU - French, Jeffrey A

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Both gestational cortisol exposure (GCE) and variability in postnatal environments can shape the later-life behavioral and endocrine outcomes of the hypothalamic-pituitary-adrenal (HPA) axis. We examined the influence of GCE and social play on HPA functioning in developing marmosets. Maternal urinary cortisol samples were collected across pregnancy to determine GCE for 28 marmoset offspring (19 litters). We administered a social separation stressor to offspring at 6, 12, and 18 months of age, during which we collected urinary cortisol samples and behavioral observations. Increased GCE was associated with increased basal cortisol levels and cortisol reactivity, but the strength of this relationship decreased across age. Increased social play was associated with decreased basal cortisol levels and a marginally greater reduction in cortisol reactivity as offspring aged, regardless of offspring GCE. Thus, GCE is associated with HPA functioning, but socially enriching postnatal environments can alter the effects associated with increased fetal exposure to glucocorticoids.

AB - Both gestational cortisol exposure (GCE) and variability in postnatal environments can shape the later-life behavioral and endocrine outcomes of the hypothalamic-pituitary-adrenal (HPA) axis. We examined the influence of GCE and social play on HPA functioning in developing marmosets. Maternal urinary cortisol samples were collected across pregnancy to determine GCE for 28 marmoset offspring (19 litters). We administered a social separation stressor to offspring at 6, 12, and 18 months of age, during which we collected urinary cortisol samples and behavioral observations. Increased GCE was associated with increased basal cortisol levels and cortisol reactivity, but the strength of this relationship decreased across age. Increased social play was associated with decreased basal cortisol levels and a marginally greater reduction in cortisol reactivity as offspring aged, regardless of offspring GCE. Thus, GCE is associated with HPA functioning, but socially enriching postnatal environments can alter the effects associated with increased fetal exposure to glucocorticoids.

KW - Cortisol reactivity

KW - Development

KW - Fetal programming

KW - HPA axis

KW - Marmoset

KW - Non-human primate

KW - Prenatal cortisol

KW - Social play

UR - http://www.scopus.com/inward/record.url?scp=84905215643&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905215643&partnerID=8YFLogxK

U2 - 10.1002/dev.21203

DO - 10.1002/dev.21203

M3 - Article

VL - 56

SP - 1229

EP - 1243

JO - Developmental Psychobiology

JF - Developmental Psychobiology

SN - 0012-1630

IS - 6

ER -