Abstract

Germ cell tumour, though rare, represents most common malignancy among young men aged between 15 to 35 years. In 1990's dramatic improvement has taken place in survival rate of testicular tumours (from 10% in 1970's and 90% in 1990's). This has been possible because of effective diagnostic techniques, accurate monitoring with biological markers and use of effective platinum based combination chemotherapy in its management. The most significant improvement in survival rate has occurred in advanced stage germ-cell tumours. Seminomas are sensitive to radiation therapy and NSGCT (Non Seminomatous Germ Cell Tumours). are effectively treated by combination chemotherapy of 3 drugs of which Bleomycin is most expensive and many patient can not afford it and so compliance is poor. In the present series we have tried only 2 drug regimen consisting of Platinum and Etoposide (PE). Since January 1992 to December 1994, 40 cases of testicular tumours were treated. 16 cases received PEB regimen and 24 cases were treated by PE regimen of which only 6 cases in the former and 20 cases in the later group completed the scheduled course. Patients were given 6 cycles of PE regimen (inj. Platinum 20 mg/m2 D1-D5, VP-16 (ETOPOSIDE), 100 MG/M2 1.V. D1-D5) repeated every three weeks. Final evaluation was done in June 1996. 17/20 (85%) patients on PE regiment exhibited complete regression of the disease by the end of June 1996, I was lost to follow up, and 2 of them had the disease in progressive stage and were considered for another regimen. 18 months disease free survival was 85%. Table I. Royal Marsden Staging System Stage I: Disease econfined to testes Stage II: Intradiaphragmatic node involvement A: Less than 2 cm B: 2-5 cm C: Greater than 5 cm Stage III: Supradiaphragmatic node involvement Stage IV: Extralymphatic disease Lung, Liver, Bone etc.

Original languageEnglish (US)
Pages (from-to)406-411
Number of pages6
JournalIndian journal of medical sciences
Volume52
Issue number9
StatePublished - Sep 1998

Fingerprint

Germ Cell and Embryonal Neoplasms
Platinum
Etoposide
Testis
Testicular Neoplasms
Combination Drug Therapy
Survival Rate
Seminoma
Lost to Follow-Up
Bleomycin
Pharmaceutical Preparations
Lung Diseases
Compliance
Disease-Free Survival
Liver Diseases
Radiotherapy
Biomarkers
Bone and Bones
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Singh, K. K., Asthana, A. K., Chandra, A., & Singh, R. K. (1998). Germ cell tumour of testis. Indian journal of medical sciences, 52(9), 406-411.

Germ cell tumour of testis. / Singh, K. K.; Asthana, A. K.; Chandra, A.; Singh, R. K.

In: Indian journal of medical sciences, Vol. 52, No. 9, 09.1998, p. 406-411.

Research output: Contribution to journalArticle

Singh, KK, Asthana, AK, Chandra, A & Singh, RK 1998, 'Germ cell tumour of testis.', Indian journal of medical sciences, vol. 52, no. 9, pp. 406-411.
Singh KK, Asthana AK, Chandra A, Singh RK. Germ cell tumour of testis. Indian journal of medical sciences. 1998 Sep;52(9):406-411.
Singh, K. K. ; Asthana, A. K. ; Chandra, A. ; Singh, R. K. / Germ cell tumour of testis. In: Indian journal of medical sciences. 1998 ; Vol. 52, No. 9. pp. 406-411.
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