Geographic patterns of cancer in the population-based registry of Egypt: Possible links to environmental exposures

Subhojit Dey, Zhenzhen Zhang, Ahmed Hablas, Ibrahim A. Seifeldein, Mohamed Ramadan, Hesham El-Hamzawy, Amr S. Soliman

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22 Scopus citations

Abstract

Background: We investigated the variation in cancer incidence in Gharbiah, Egypt to explore geographic differences in relation to demographic and environmental exposures. Methods: Using data from the only population-based cancer registry of Gharbiah, we studied the 10 most common cancers in men and women over 4 years (1999-2002). Census data provided denominators and urban-rural definitions. Crude and adjusted incidence rates (IRs), incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were estimated using Poisson regression. Results: Incidence of all common cancers was higher among men than women and urban incidence was higher than rural incidence for all cancer sites. Among men and women urban-rural incidence difference was highest for prostate cancer (IRR. = 4.85, 95% CI. = 3.76, 6.26) and uterus (IRR. = 6.05, 95% CI. = 4.17, 8.78), respectively. Among men and women, El-Santa district had the highest urban-rural difference within districts for laryngeal cancer (IRR. = 29.45, 95% CI. = 10.63, 81.61) and uterine cancer (IRR. = 15.98, 95% CI. = 2.69, 95.10), respectively. El-Santa also showed the highest urban incidence among all eight districts for most cancer sites. Conclusions: Geographic differences of cancers in Gharbiah need in-depth investigation with respect to specific environmental factors that explain the geographic cancer in this region.

Original languageEnglish (US)
Pages (from-to)254-264
Number of pages11
JournalCancer Epidemiology
Volume35
Issue number3
DOIs
Publication statusPublished - Jun 1 2011

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Keywords

  • Cancer
  • Cancer registries
  • Developing countries
  • Egypt
  • Environmental exposures
  • Geographic pattern

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Cancer Research

Cite this

Dey, S., Zhang, Z., Hablas, A., Seifeldein, I. A., Ramadan, M., El-Hamzawy, H., & Soliman, A. S. (2011). Geographic patterns of cancer in the population-based registry of Egypt: Possible links to environmental exposures. Cancer Epidemiology, 35(3), 254-264. https://doi.org/10.1016/j.canep.2010.09.010