Geographic patterns of cancer in the population-based registry of Egypt

Possible links to environmental exposures

Subhojit Dey, Zhenzhen Zhang, Ahmed Hablas, Ibrahim A. Seifeldein, Mohamed Ramadan, Hesham El-Hamzawy, Amr S Soliman

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: We investigated the variation in cancer incidence in Gharbiah, Egypt to explore geographic differences in relation to demographic and environmental exposures. Methods: Using data from the only population-based cancer registry of Gharbiah, we studied the 10 most common cancers in men and women over 4 years (1999-2002). Census data provided denominators and urban-rural definitions. Crude and adjusted incidence rates (IRs), incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were estimated using Poisson regression. Results: Incidence of all common cancers was higher among men than women and urban incidence was higher than rural incidence for all cancer sites. Among men and women urban-rural incidence difference was highest for prostate cancer (IRR. = 4.85, 95% CI. = 3.76, 6.26) and uterus (IRR. = 6.05, 95% CI. = 4.17, 8.78), respectively. Among men and women, El-Santa district had the highest urban-rural difference within districts for laryngeal cancer (IRR. = 29.45, 95% CI. = 10.63, 81.61) and uterine cancer (IRR. = 15.98, 95% CI. = 2.69, 95.10), respectively. El-Santa also showed the highest urban incidence among all eight districts for most cancer sites. Conclusions: Geographic differences of cancers in Gharbiah need in-depth investigation with respect to specific environmental factors that explain the geographic cancer in this region.

Original languageEnglish (US)
Pages (from-to)254-264
Number of pages11
JournalCancer Epidemiology
Volume35
Issue number3
DOIs
StatePublished - Jun 1 2011

Fingerprint

Egypt
Environmental Exposure
Registries
Incidence
Population
Neoplasms
Confidence Intervals
Uterine Neoplasms
Geography
Laryngeal Neoplasms
Censuses
Uterus
Prostatic Neoplasms
Demography

Keywords

  • Cancer
  • Cancer registries
  • Developing countries
  • Egypt
  • Environmental exposures
  • Geographic pattern

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Cancer Research

Cite this

Dey, S., Zhang, Z., Hablas, A., Seifeldein, I. A., Ramadan, M., El-Hamzawy, H., & Soliman, A. S. (2011). Geographic patterns of cancer in the population-based registry of Egypt: Possible links to environmental exposures. Cancer Epidemiology, 35(3), 254-264. https://doi.org/10.1016/j.canep.2010.09.010

Geographic patterns of cancer in the population-based registry of Egypt : Possible links to environmental exposures. / Dey, Subhojit; Zhang, Zhenzhen; Hablas, Ahmed; Seifeldein, Ibrahim A.; Ramadan, Mohamed; El-Hamzawy, Hesham; Soliman, Amr S.

In: Cancer Epidemiology, Vol. 35, No. 3, 01.06.2011, p. 254-264.

Research output: Contribution to journalArticle

Dey, S, Zhang, Z, Hablas, A, Seifeldein, IA, Ramadan, M, El-Hamzawy, H & Soliman, AS 2011, 'Geographic patterns of cancer in the population-based registry of Egypt: Possible links to environmental exposures', Cancer Epidemiology, vol. 35, no. 3, pp. 254-264. https://doi.org/10.1016/j.canep.2010.09.010
Dey, Subhojit ; Zhang, Zhenzhen ; Hablas, Ahmed ; Seifeldein, Ibrahim A. ; Ramadan, Mohamed ; El-Hamzawy, Hesham ; Soliman, Amr S. / Geographic patterns of cancer in the population-based registry of Egypt : Possible links to environmental exposures. In: Cancer Epidemiology. 2011 ; Vol. 35, No. 3. pp. 254-264.
@article{f1b91b4ad9534254b1914eabe92e714b,
title = "Geographic patterns of cancer in the population-based registry of Egypt: Possible links to environmental exposures",
abstract = "Background: We investigated the variation in cancer incidence in Gharbiah, Egypt to explore geographic differences in relation to demographic and environmental exposures. Methods: Using data from the only population-based cancer registry of Gharbiah, we studied the 10 most common cancers in men and women over 4 years (1999-2002). Census data provided denominators and urban-rural definitions. Crude and adjusted incidence rates (IRs), incidence rate ratios (IRRs) and 95{\%} confidence intervals (CIs) were estimated using Poisson regression. Results: Incidence of all common cancers was higher among men than women and urban incidence was higher than rural incidence for all cancer sites. Among men and women urban-rural incidence difference was highest for prostate cancer (IRR. = 4.85, 95{\%} CI. = 3.76, 6.26) and uterus (IRR. = 6.05, 95{\%} CI. = 4.17, 8.78), respectively. Among men and women, El-Santa district had the highest urban-rural difference within districts for laryngeal cancer (IRR. = 29.45, 95{\%} CI. = 10.63, 81.61) and uterine cancer (IRR. = 15.98, 95{\%} CI. = 2.69, 95.10), respectively. El-Santa also showed the highest urban incidence among all eight districts for most cancer sites. Conclusions: Geographic differences of cancers in Gharbiah need in-depth investigation with respect to specific environmental factors that explain the geographic cancer in this region.",
keywords = "Cancer, Cancer registries, Developing countries, Egypt, Environmental exposures, Geographic pattern",
author = "Subhojit Dey and Zhenzhen Zhang and Ahmed Hablas and Seifeldein, {Ibrahim A.} and Mohamed Ramadan and Hesham El-Hamzawy and Soliman, {Amr S}",
year = "2011",
month = "6",
day = "1",
doi = "10.1016/j.canep.2010.09.010",
language = "English (US)",
volume = "35",
pages = "254--264",
journal = "Cancer Epidemiology",
issn = "1877-7821",
publisher = "Elsevier BV",
number = "3",

}

TY - JOUR

T1 - Geographic patterns of cancer in the population-based registry of Egypt

T2 - Possible links to environmental exposures

AU - Dey, Subhojit

AU - Zhang, Zhenzhen

AU - Hablas, Ahmed

AU - Seifeldein, Ibrahim A.

AU - Ramadan, Mohamed

AU - El-Hamzawy, Hesham

AU - Soliman, Amr S

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Background: We investigated the variation in cancer incidence in Gharbiah, Egypt to explore geographic differences in relation to demographic and environmental exposures. Methods: Using data from the only population-based cancer registry of Gharbiah, we studied the 10 most common cancers in men and women over 4 years (1999-2002). Census data provided denominators and urban-rural definitions. Crude and adjusted incidence rates (IRs), incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were estimated using Poisson regression. Results: Incidence of all common cancers was higher among men than women and urban incidence was higher than rural incidence for all cancer sites. Among men and women urban-rural incidence difference was highest for prostate cancer (IRR. = 4.85, 95% CI. = 3.76, 6.26) and uterus (IRR. = 6.05, 95% CI. = 4.17, 8.78), respectively. Among men and women, El-Santa district had the highest urban-rural difference within districts for laryngeal cancer (IRR. = 29.45, 95% CI. = 10.63, 81.61) and uterine cancer (IRR. = 15.98, 95% CI. = 2.69, 95.10), respectively. El-Santa also showed the highest urban incidence among all eight districts for most cancer sites. Conclusions: Geographic differences of cancers in Gharbiah need in-depth investigation with respect to specific environmental factors that explain the geographic cancer in this region.

AB - Background: We investigated the variation in cancer incidence in Gharbiah, Egypt to explore geographic differences in relation to demographic and environmental exposures. Methods: Using data from the only population-based cancer registry of Gharbiah, we studied the 10 most common cancers in men and women over 4 years (1999-2002). Census data provided denominators and urban-rural definitions. Crude and adjusted incidence rates (IRs), incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were estimated using Poisson regression. Results: Incidence of all common cancers was higher among men than women and urban incidence was higher than rural incidence for all cancer sites. Among men and women urban-rural incidence difference was highest for prostate cancer (IRR. = 4.85, 95% CI. = 3.76, 6.26) and uterus (IRR. = 6.05, 95% CI. = 4.17, 8.78), respectively. Among men and women, El-Santa district had the highest urban-rural difference within districts for laryngeal cancer (IRR. = 29.45, 95% CI. = 10.63, 81.61) and uterine cancer (IRR. = 15.98, 95% CI. = 2.69, 95.10), respectively. El-Santa also showed the highest urban incidence among all eight districts for most cancer sites. Conclusions: Geographic differences of cancers in Gharbiah need in-depth investigation with respect to specific environmental factors that explain the geographic cancer in this region.

KW - Cancer

KW - Cancer registries

KW - Developing countries

KW - Egypt

KW - Environmental exposures

KW - Geographic pattern

UR - http://www.scopus.com/inward/record.url?scp=79955993887&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955993887&partnerID=8YFLogxK

U2 - 10.1016/j.canep.2010.09.010

DO - 10.1016/j.canep.2010.09.010

M3 - Article

VL - 35

SP - 254

EP - 264

JO - Cancer Epidemiology

JF - Cancer Epidemiology

SN - 1877-7821

IS - 3

ER -