Abstract
The appropriate dosing of gentamicin in the newborn was evaluated. Gentamicin was administered intramuscularly to 151 neonates ranging in birthweight from 0.66 to 4.7 kg (gestational age, 26-42 weeks) during a 7-month period. A dosage of 2.5 mg/kg of birthweight every 12 hours was initiated at birth until gentamicin serum levels could be determined. These infants were divided into three groups based on birthweight: 1) d 1000 gm; 2) 1001-2000 gm; 3) > 2000 gm. From gentamicin serum level data, these three groups had significantly different (P < 0.05) gentamicin half-lives. Based on the desirability of maintaining a trough gentamicin serum level < 2, 100, 95.5, and 39% of infants in groups 1, 2, and 3, respectively, required initial dosing interval adjustments. A second group of 74 infants whose birthweight ranged from 0.82 to 3.9 kg (gestational age, 26-42 weeks) required aminoglycoside therapy and were prospectively placed on gentamicin 2.5 mg/kg of birthweight on the following schedule: 1) d 1000 gm every 24 hours; 2) 1001-2000 gm every 18 hours; 3) > 2000 gm every 12 hours. Using this method, only 15, 58, and 33% of infants in groups 1, 2, and 3, respectively, required dosing interval changes. We conclude that a marked reduction in undesirably high trough gentamicin serum levels can be affected by a simple change in dosing interval based on birthweight, although gentamicin serum levels are still required due to a significant number of infants with high trough levels.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 28-32 |
| Number of pages | 5 |
| Journal | American Journal of Perinatology |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1986 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynecology
Cite this
Gentamicin Dosage Recommendations for Neonates Based on Half-Life Predictions from Birthweight. / Charlton, Christopher K.; Needelman, Howard; Thomas, Russel W.; Kortas, Kenneth.
In: American Journal of Perinatology, Vol. 3, No. 1, 01.1986, p. 28-32.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gentamicin Dosage Recommendations for Neonates Based on Half-Life Predictions from Birthweight
AU - Charlton, Christopher K.
AU - Needelman, Howard
AU - Thomas, Russel W.
AU - Kortas, Kenneth
PY - 1986/1
Y1 - 1986/1
N2 - The appropriate dosing of gentamicin in the newborn was evaluated. Gentamicin was administered intramuscularly to 151 neonates ranging in birthweight from 0.66 to 4.7 kg (gestational age, 26-42 weeks) during a 7-month period. A dosage of 2.5 mg/kg of birthweight every 12 hours was initiated at birth until gentamicin serum levels could be determined. These infants were divided into three groups based on birthweight: 1) d 1000 gm; 2) 1001-2000 gm; 3) > 2000 gm. From gentamicin serum level data, these three groups had significantly different (P < 0.05) gentamicin half-lives. Based on the desirability of maintaining a trough gentamicin serum level < 2, 100, 95.5, and 39% of infants in groups 1, 2, and 3, respectively, required initial dosing interval adjustments. A second group of 74 infants whose birthweight ranged from 0.82 to 3.9 kg (gestational age, 26-42 weeks) required aminoglycoside therapy and were prospectively placed on gentamicin 2.5 mg/kg of birthweight on the following schedule: 1) d 1000 gm every 24 hours; 2) 1001-2000 gm every 18 hours; 3) > 2000 gm every 12 hours. Using this method, only 15, 58, and 33% of infants in groups 1, 2, and 3, respectively, required dosing interval changes. We conclude that a marked reduction in undesirably high trough gentamicin serum levels can be affected by a simple change in dosing interval based on birthweight, although gentamicin serum levels are still required due to a significant number of infants with high trough levels.
AB - The appropriate dosing of gentamicin in the newborn was evaluated. Gentamicin was administered intramuscularly to 151 neonates ranging in birthweight from 0.66 to 4.7 kg (gestational age, 26-42 weeks) during a 7-month period. A dosage of 2.5 mg/kg of birthweight every 12 hours was initiated at birth until gentamicin serum levels could be determined. These infants were divided into three groups based on birthweight: 1) d 1000 gm; 2) 1001-2000 gm; 3) > 2000 gm. From gentamicin serum level data, these three groups had significantly different (P < 0.05) gentamicin half-lives. Based on the desirability of maintaining a trough gentamicin serum level < 2, 100, 95.5, and 39% of infants in groups 1, 2, and 3, respectively, required initial dosing interval adjustments. A second group of 74 infants whose birthweight ranged from 0.82 to 3.9 kg (gestational age, 26-42 weeks) required aminoglycoside therapy and were prospectively placed on gentamicin 2.5 mg/kg of birthweight on the following schedule: 1) d 1000 gm every 24 hours; 2) 1001-2000 gm every 18 hours; 3) > 2000 gm every 12 hours. Using this method, only 15, 58, and 33% of infants in groups 1, 2, and 3, respectively, required dosing interval changes. We conclude that a marked reduction in undesirably high trough gentamicin serum levels can be affected by a simple change in dosing interval based on birthweight, although gentamicin serum levels are still required due to a significant number of infants with high trough levels.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022611982&partnerID=8YFLogxK
U2 - 10.1055/s-2007-999820
DO - 10.1055/s-2007-999820
M3 - Article
C2 - 3942611
AN - SCOPUS:0022611982
VL - 3
SP - 28
EP - 32
JO - American Journal of Perinatology
JF - American Journal of Perinatology
SN - 0735-1631
IS - 1
ER -