Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula

M. P. Dempsey, M. Dobson, C. Zhang, M. Zhang, C. Lion, C. B. Gutiérrez-Martín, Peter Charles Iwen, Paul D Fey, M. E. Olson, D. Niemeyer, S. Francesconi, R. Crawford, M. Stanley, J. Rhodes, D. M. Wagner, A. J. Vogler, D. Birdsell, P. Keim, A. Johansson, Steven Heye Hinrichs & 1 others Andrew K Benson

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Francisella tularensis subsp. holarctica is widely disseminated in North America and the boreal and temperate regions of the Eurasian continent. Comparative genomic analyses identified a 1.59-kb genomic deletion specific to F. tularensis subsp. holarctica isolates from Spain and France. Phylogenetic analysis of strains carrying this deletion by multiple-locus variable-number tandem repeat analysis showed that the strains comprise a highly related set of genotypes, implying that these strains were recently introduced or recently emerged by clonal expansion in France and the Iberian Peninsula.

Original languageEnglish (US)
Pages (from-to)7465-7470
Number of pages6
JournalApplied and environmental microbiology
Volume73
Issue number22
DOIs
StatePublished - Nov 1 2007

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Francisella tularensis subsp. holarctica
Francisella tularensis
Iberian Peninsula
France
genomics
Minisatellite Repeats
North America
Spain
genotype
Genotype
phylogenetics
phylogeny
analysis

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology
  • Ecology

Cite this

Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula. / Dempsey, M. P.; Dobson, M.; Zhang, C.; Zhang, M.; Lion, C.; Gutiérrez-Martín, C. B.; Iwen, Peter Charles; Fey, Paul D; Olson, M. E.; Niemeyer, D.; Francesconi, S.; Crawford, R.; Stanley, M.; Rhodes, J.; Wagner, D. M.; Vogler, A. J.; Birdsell, D.; Keim, P.; Johansson, A.; Hinrichs, Steven Heye; Benson, Andrew K.

In: Applied and environmental microbiology, Vol. 73, No. 22, 01.11.2007, p. 7465-7470.

Research output: Contribution to journalArticle

Dempsey, MP, Dobson, M, Zhang, C, Zhang, M, Lion, C, Gutiérrez-Martín, CB, Iwen, PC, Fey, PD, Olson, ME, Niemeyer, D, Francesconi, S, Crawford, R, Stanley, M, Rhodes, J, Wagner, DM, Vogler, AJ, Birdsell, D, Keim, P, Johansson, A, Hinrichs, SH & Benson, AK 2007, 'Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula', Applied and environmental microbiology, vol. 73, no. 22, pp. 7465-7470. https://doi.org/10.1128/AEM.00646-07
Dempsey, M. P. ; Dobson, M. ; Zhang, C. ; Zhang, M. ; Lion, C. ; Gutiérrez-Martín, C. B. ; Iwen, Peter Charles ; Fey, Paul D ; Olson, M. E. ; Niemeyer, D. ; Francesconi, S. ; Crawford, R. ; Stanley, M. ; Rhodes, J. ; Wagner, D. M. ; Vogler, A. J. ; Birdsell, D. ; Keim, P. ; Johansson, A. ; Hinrichs, Steven Heye ; Benson, Andrew K. / Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula. In: Applied and environmental microbiology. 2007 ; Vol. 73, No. 22. pp. 7465-7470.
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