Genomic aberrations affecting the outcome of immunodeficiency-related diffuse large B-cell lymphoma

Ivo Kwee, Daniela Capello, Andrea Rinaldi, Paola M V Rancoita, Govind Bhagat, Timothy Charles Greiner, Michele Spina, Annunziata Gloghini, Wing C. Chan, Marco Paulli, Emanuele Zucca, Umberto Tirelli, Antonino Carbone, Gianluca Gaidano, Francesco Bertoni

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The objective of this study was to evaluate the prognostic impact of genomic regions in a series of human immunodeficiency virus (HIV)-related diffuse large B-cell lymphomas (HIV-DLBCLs) and post-transplant DLBCLs (PT-DLBCLs) analyzed by genome-wide DNA profiling. Minimal common regions (MCRs) were estimated on genomic profiles obtained using Affymetrix Human Mapping 250k Nsp I arrays and tested for their impact on clinical outcome by univariate analysis on 36 PT-DLBCLs, 19 HIV-DLBCLs and, as a control group, 149 DLBCLs arising in immunocompetent individuals (IC-DLBCLs). PT-DLBCL and HIV-DLBCL presented a similar outcome. Immunodeficiency-related DLBCL (ID-DLBCL) had a worse overall survival (OS) than IC-DLBCL. Seven MCRs showed a statistical impact on OS in PT-DLBCL and four in HIV-DLBCL. Among these, the presence of gains at 1q or at 18q defined a group of patients with PT-DLBCL with a very poor outcome (p < 0.0001). The presence of del(3p14.2) or of + 2p23.1 identified a group of HIV-DLBCLs with a very poor outcome (p = 0.0072). It was concluded that genomic aberrations affecting outcome differ between ID-DLBCL and IC-DLBCL and are also dependent on the type of acquired immunodeficiency.

Original languageEnglish (US)
Pages (from-to)71-76
Number of pages6
JournalLeukemia and Lymphoma
Volume53
Issue number1
DOIs
StatePublished - Jan 1 2012

Fingerprint

Lymphoma, Large B-Cell, Diffuse
HIV
Transplants
Survival
DNA Fingerprinting
Genome
Control Groups

Keywords

  • Diffuse large B-cell lymphoma
  • FHIT
  • HIV
  • Immunodeficiency
  • Lymphoma
  • Organ transplant
  • Outcome

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Genomic aberrations affecting the outcome of immunodeficiency-related diffuse large B-cell lymphoma. / Kwee, Ivo; Capello, Daniela; Rinaldi, Andrea; Rancoita, Paola M V; Bhagat, Govind; Greiner, Timothy Charles; Spina, Michele; Gloghini, Annunziata; Chan, Wing C.; Paulli, Marco; Zucca, Emanuele; Tirelli, Umberto; Carbone, Antonino; Gaidano, Gianluca; Bertoni, Francesco.

In: Leukemia and Lymphoma, Vol. 53, No. 1, 01.01.2012, p. 71-76.

Research output: Contribution to journalArticle

Kwee, I, Capello, D, Rinaldi, A, Rancoita, PMV, Bhagat, G, Greiner, TC, Spina, M, Gloghini, A, Chan, WC, Paulli, M, Zucca, E, Tirelli, U, Carbone, A, Gaidano, G & Bertoni, F 2012, 'Genomic aberrations affecting the outcome of immunodeficiency-related diffuse large B-cell lymphoma', Leukemia and Lymphoma, vol. 53, no. 1, pp. 71-76. https://doi.org/10.3109/10428194.2011.607729
Kwee, Ivo ; Capello, Daniela ; Rinaldi, Andrea ; Rancoita, Paola M V ; Bhagat, Govind ; Greiner, Timothy Charles ; Spina, Michele ; Gloghini, Annunziata ; Chan, Wing C. ; Paulli, Marco ; Zucca, Emanuele ; Tirelli, Umberto ; Carbone, Antonino ; Gaidano, Gianluca ; Bertoni, Francesco. / Genomic aberrations affecting the outcome of immunodeficiency-related diffuse large B-cell lymphoma. In: Leukemia and Lymphoma. 2012 ; Vol. 53, No. 1. pp. 71-76.
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