Genome-wide prediction of age at puberty and reproductive longevity in sows

J. K. Tart, R. K. Johnson, J. W. Bundy, N. N. Ferdinand, A. M. McKnite, Jennifer R Wood, Phillip S Miller, M. F. Rothschild, M. L. Spangler, D. J. Garrick, Stephen D Kachman, Daniel C Ciobanu

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Traditional selection for sow reproductive longevity is ineffective due to low heritability and late expression of the trait. Incorporation of DNA markers into selection programs is potentially a more practical approach for improving sow lifetime productivity. Using a resource population of crossbred gilts, we explored pleiotropic sources of variation that influence age at puberty and reproductive longevity. Of the traits recorded before breeding, only age at puberty significantly affected the probability that females would produce a first parity litter. The genetic variance explained by 1-Mb windows of the sow genome, compared across traits, uncovered regions that influence both age at puberty and lifetime number of parities. Allelic variants of SNPs located on SSC5 (27-28 Mb), SSC8 (36-37 Mb) and SSC12 (1.2-2 Mb) exhibited additive effects and were associated with both early expression of puberty and a greater than average number of lifetime parities. Combined analysis of these SNPs showed that an increase in the number of favorable alleles had positive impact on reproductive longevity, increasing number of parities by up to 1.36. The region located on SSC5 harbors non-synonymous alleles in the arginine vasopressin receptor 1A (AVPR1A) gene, a G-protein-coupled receptor associated with social and reproductive behaviors in voles and humans and a candidate for the observed effects. This region is characterized by high levels of linkage disequilibrium in different lines and could be exploited in marker-assisted selection programs across populations to increase sow reproductive longevity.

Original languageEnglish (US)
Pages (from-to)387-397
Number of pages11
JournalAnimal genetics
Volume44
Issue number4
DOIs
StatePublished - Aug 1 2013

Fingerprint

puberty
Puberty
parity (reproduction)
Parity
sows
Genome
genome
prediction
Single Nucleotide Polymorphism
Alleles
alleles
arginine vasopressin
Reproductive Behavior
Vasopressin Receptors
Arvicolinae
Population Control
Social Behavior
Linkage Disequilibrium
reproductive behavior
linkage disequilibrium

Keywords

  • DNA
  • genetics
  • genome-wide association
  • marker
  • pig
  • reproduction

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Genetics

Cite this

Tart, J. K., Johnson, R. K., Bundy, J. W., Ferdinand, N. N., McKnite, A. M., Wood, J. R., ... Ciobanu, D. C. (2013). Genome-wide prediction of age at puberty and reproductive longevity in sows. Animal genetics, 44(4), 387-397. https://doi.org/10.1111/age.12028

Genome-wide prediction of age at puberty and reproductive longevity in sows. / Tart, J. K.; Johnson, R. K.; Bundy, J. W.; Ferdinand, N. N.; McKnite, A. M.; Wood, Jennifer R; Miller, Phillip S; Rothschild, M. F.; Spangler, M. L.; Garrick, D. J.; Kachman, Stephen D; Ciobanu, Daniel C.

In: Animal genetics, Vol. 44, No. 4, 01.08.2013, p. 387-397.

Research output: Contribution to journalArticle

Tart, JK, Johnson, RK, Bundy, JW, Ferdinand, NN, McKnite, AM, Wood, JR, Miller, PS, Rothschild, MF, Spangler, ML, Garrick, DJ, Kachman, SD & Ciobanu, DC 2013, 'Genome-wide prediction of age at puberty and reproductive longevity in sows', Animal genetics, vol. 44, no. 4, pp. 387-397. https://doi.org/10.1111/age.12028
Tart JK, Johnson RK, Bundy JW, Ferdinand NN, McKnite AM, Wood JR et al. Genome-wide prediction of age at puberty and reproductive longevity in sows. Animal genetics. 2013 Aug 1;44(4):387-397. https://doi.org/10.1111/age.12028
Tart, J. K. ; Johnson, R. K. ; Bundy, J. W. ; Ferdinand, N. N. ; McKnite, A. M. ; Wood, Jennifer R ; Miller, Phillip S ; Rothschild, M. F. ; Spangler, M. L. ; Garrick, D. J. ; Kachman, Stephen D ; Ciobanu, Daniel C. / Genome-wide prediction of age at puberty and reproductive longevity in sows. In: Animal genetics. 2013 ; Vol. 44, No. 4. pp. 387-397.
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