Genome scans of DNA variability in humans reveal evidence for selective sweeps outside of Africa

Jay F. Storz, Bret A. Payseur, Michael W. Nachman

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

The last 50,000-150,000 years of human history have been characterized by rapid demographic expansions and the colonization of novel environments outside of sub-Saharan Africa. Mass migrations outside the ancestral species range likely entailed many new selection pressures, suggesting that genetic adaptation to local environmental conditions may have been more prevalent in colonizing populations outside of sub-Saharan Africa. Here we report a test of this hypothesis using genome-wide patterns of DNA polymorphism. We conducted a multilocus scan of microsatellite variability to identify regions of the human genome that may have been subject to continent-specific hitchhiking events. Using published polymorphism data for a total of 624 autosomal loci in multiple populations of humans, we used coalescent simulations to identify candidate loci for geographically restricted selective sweeps. We identified a total of 13 loci that appeared as outliers in replicated population comparisons involving different reference samples for Africa. A disproportionate number of these loci exhibited reduced levels of relative variability in non-African populations alone, suggesting that recent episodes of positive selection have been more prevalent outside of sub-Saharan Africa.

Original languageEnglish (US)
Pages (from-to)1800-1811
Number of pages12
JournalMolecular biology and evolution
Volume21
Issue number9
DOIs
StatePublished - Sep 1 2004

Fingerprint

Polymorphism
Africa South of the Sahara
Sub-Saharan Africa
genome
Genes
Genome
DNA
loci
Microsatellite Repeats
Population
polymorphism
genetic polymorphism
reference sample
Human Genome
outlier
human population
demographic statistics
colonization
History
environmental conditions

Keywords

  • Adaptation
  • Genetic hitchhiking
  • Human genome
  • Microsatellite DNA
  • Natural selection
  • Positive selection

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

Cite this

Genome scans of DNA variability in humans reveal evidence for selective sweeps outside of Africa. / Storz, Jay F.; Payseur, Bret A.; Nachman, Michael W.

In: Molecular biology and evolution, Vol. 21, No. 9, 01.09.2004, p. 1800-1811.

Research output: Contribution to journalArticle

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