Genetically engineered mucin mouse models for inflammation and cancer

Suhasini Joshi, Sushil Kumar, Sangeeta Bafna, Satyanarayana Rachagani, Kay Uwe Wagner, Maneesh Jain, Surinder K. Batra

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Mucins are heavily O-glycosylated proteins primarily produced by glandular and ductal epithelial cells, either in membrane-tethered or secretory forms, for providing lubrication and protection from various exogenous and endogenous insults. However, recent studies have linked their aberrant overexpression with infection, inflammation, and cancer that underscores their importance in tissue homeostasis. In this review, we present current status of the existing mouse models that have been developed to gain insights into the functional role(s) of mucins under physiological and pathological conditions. Knockout mouse models for membrane-associated (Muc1 and Muc16) and secretory mucins (Muc2) have helped us to elucidate the role of mucins in providing effective and protective barrier functions against pathological threats, participation in disease progression, and improved our understanding of mucin interaction with biotic and abiotic environmental components. Emphasis is also given to available transgenic mouse models (MUC1 and MUC7), which has been exploited to understand the context-dependent regulation and therapeutic potential of human mucins during inflammation and cancer.

Original languageEnglish (US)
Pages (from-to)593-609
Number of pages17
JournalCancer and Metastasis Reviews
Volume34
Issue number4
DOIs
StatePublished - Dec 1 2015

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Keywords

  • Cancer
  • Knockout models
  • Mucins
  • Synteny
  • Transgenic mice models
  • Vaccines

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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