Genetic variation in pneumocystis carinii isolates from different geographic regions

Implications for transmission

Charles B. Beard, Jane L. Carter, Scott P. Keely, Laurence Huang, Norman J. Pieniazek, Iaci N.S. Moura, Jacquelin M. Roberts, Allen W. Hightower, Michelle S. Bens, Amanda R. Freeman, Sherline Lee, James R. Stringer, Jeffrey S. Duchin, Carlos Del Rio, David Rimland, Robert P. Baughman, Deborah A Levy, Vance J. Dietz, Paul Simon, Thomas R. Navin

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

To study transmission patterns of Pneumocystis carinii pneumonia (PCP) in persons with AIDS, we evaluated P. carinii isolates from patients in five U.S. cities for variation at two independent genetic loci, the mitochondrial large subunit rRNA and dihydropteroate synthase. Fourteen unique multilocus genotypes were observed in 191 isolates that were examined at both loci. Mixed infections, accounting for 17.8% of cases, were associated with primary PCP. Genotype frequency distribution patterns varied by patients' place of diagnosis but not by place of birth. Genetic variation at the two loci suggests three probable characteristics of transmission: that most cases of PCP do not result from infections acquired early in life, that infections are actively acquired from a relatively common source (humans or the environment), and that humans, while not necessarily involved in direct infection of other humans, are nevertheless important in the transmission cycle of P. carinii f. sp. hominis.

Original languageEnglish (US)
Pages (from-to)265-272
Number of pages8
JournalEmerging infectious diseases
Volume6
Issue number3
DOIs
StatePublished - Jan 1 2000

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Pneumocystis carinii
Pneumocystis Pneumonia
Dihydropteroate Synthase
Infection
Genotype
Genetic Loci
Coinfection
Acquired Immunodeficiency Syndrome

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Beard, C. B., Carter, J. L., Keely, S. P., Huang, L., Pieniazek, N. J., Moura, I. N. S., ... Navin, T. R. (2000). Genetic variation in pneumocystis carinii isolates from different geographic regions: Implications for transmission. Emerging infectious diseases, 6(3), 265-272. https://doi.org/10.3201/eid0603.000306

Genetic variation in pneumocystis carinii isolates from different geographic regions : Implications for transmission. / Beard, Charles B.; Carter, Jane L.; Keely, Scott P.; Huang, Laurence; Pieniazek, Norman J.; Moura, Iaci N.S.; Roberts, Jacquelin M.; Hightower, Allen W.; Bens, Michelle S.; Freeman, Amanda R.; Lee, Sherline; Stringer, James R.; Duchin, Jeffrey S.; Del Rio, Carlos; Rimland, David; Baughman, Robert P.; Levy, Deborah A; Dietz, Vance J.; Simon, Paul; Navin, Thomas R.

In: Emerging infectious diseases, Vol. 6, No. 3, 01.01.2000, p. 265-272.

Research output: Contribution to journalArticle

Beard, CB, Carter, JL, Keely, SP, Huang, L, Pieniazek, NJ, Moura, INS, Roberts, JM, Hightower, AW, Bens, MS, Freeman, AR, Lee, S, Stringer, JR, Duchin, JS, Del Rio, C, Rimland, D, Baughman, RP, Levy, DA, Dietz, VJ, Simon, P & Navin, TR 2000, 'Genetic variation in pneumocystis carinii isolates from different geographic regions: Implications for transmission', Emerging infectious diseases, vol. 6, no. 3, pp. 265-272. https://doi.org/10.3201/eid0603.000306
Beard, Charles B. ; Carter, Jane L. ; Keely, Scott P. ; Huang, Laurence ; Pieniazek, Norman J. ; Moura, Iaci N.S. ; Roberts, Jacquelin M. ; Hightower, Allen W. ; Bens, Michelle S. ; Freeman, Amanda R. ; Lee, Sherline ; Stringer, James R. ; Duchin, Jeffrey S. ; Del Rio, Carlos ; Rimland, David ; Baughman, Robert P. ; Levy, Deborah A ; Dietz, Vance J. ; Simon, Paul ; Navin, Thomas R. / Genetic variation in pneumocystis carinii isolates from different geographic regions : Implications for transmission. In: Emerging infectious diseases. 2000 ; Vol. 6, No. 3. pp. 265-272.
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