Genetic variants and susceptibility to neurological complications following West Nile virus infection

Mark Loeb, Sasha Eskandarian, Mark Edmund Rupp, Neil Fishman, Leanne Gasink, Jan Patterson, Jonathan Bramson, Thomas J. Hudson, Mathieu Lemire

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

To determine genetic factors predisposing to neurological complications following West Nile virus infection, we analyzed a cohort of 560 neuroinvasive case patients and 950 control patients for 13 371 mostly nonsynonymous single-nucleotide polymorphisms (SNPs). The top 3 SNPs on the basis of statistical significance were also in genes of biological plausibility: rs2066786 in RFC1 (replication factor C1) (P= 1.88×10-5; odds ratio [OR], 0.68 [95% confidence interval {CI}, .56-.81]); rs2298771 in SCN1A (sodium channel, neuronal type I a subunit) (P = 5.87 × 10-5; OR, 1.47 [95% CI, 1.21-1.77]); and rs25651 in ANPEP (ananyl aminopeptidase) (P = 1.44 × 10-4; OR, 0.69 [95% CI, .56-.83]). Additional genotyping of these SNPs in a separate sample of 264 case patients and 296 control patients resulted in a lack of significance in the replication cohort; joint significance was as follows: rs2066786, P = .0022; rs2298771, P = .005; rs25651, P = .042. Using mostly nonsynonymous variants, we therefore did not identify genetic variants associated with neuroinvasive disease.

Original languageEnglish (US)
Pages (from-to)1031-1037
Number of pages7
JournalJournal of Infectious Diseases
Volume204
Issue number7
DOIs
StatePublished - Oct 1 2011

Fingerprint

West Nile virus
Virus Diseases
Genetic Predisposition to Disease
Single Nucleotide Polymorphism
Odds Ratio
Confidence Intervals
Sodium Channels
Causality
Joints
Genes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Genetic variants and susceptibility to neurological complications following West Nile virus infection. / Loeb, Mark; Eskandarian, Sasha; Rupp, Mark Edmund; Fishman, Neil; Gasink, Leanne; Patterson, Jan; Bramson, Jonathan; Hudson, Thomas J.; Lemire, Mathieu.

In: Journal of Infectious Diseases, Vol. 204, No. 7, 01.10.2011, p. 1031-1037.

Research output: Contribution to journalArticle

Loeb, M, Eskandarian, S, Rupp, ME, Fishman, N, Gasink, L, Patterson, J, Bramson, J, Hudson, TJ & Lemire, M 2011, 'Genetic variants and susceptibility to neurological complications following West Nile virus infection', Journal of Infectious Diseases, vol. 204, no. 7, pp. 1031-1037. https://doi.org/10.1093/infdis/jir493
Loeb, Mark ; Eskandarian, Sasha ; Rupp, Mark Edmund ; Fishman, Neil ; Gasink, Leanne ; Patterson, Jan ; Bramson, Jonathan ; Hudson, Thomas J. ; Lemire, Mathieu. / Genetic variants and susceptibility to neurological complications following West Nile virus infection. In: Journal of Infectious Diseases. 2011 ; Vol. 204, No. 7. pp. 1031-1037.
@article{e39300bf21ad476b90d4d826bc45a378,
title = "Genetic variants and susceptibility to neurological complications following West Nile virus infection",
abstract = "To determine genetic factors predisposing to neurological complications following West Nile virus infection, we analyzed a cohort of 560 neuroinvasive case patients and 950 control patients for 13 371 mostly nonsynonymous single-nucleotide polymorphisms (SNPs). The top 3 SNPs on the basis of statistical significance were also in genes of biological plausibility: rs2066786 in RFC1 (replication factor C1) (P= 1.88×10-5; odds ratio [OR], 0.68 [95{\%} confidence interval {CI}, .56-.81]); rs2298771 in SCN1A (sodium channel, neuronal type I a subunit) (P = 5.87 × 10-5; OR, 1.47 [95{\%} CI, 1.21-1.77]); and rs25651 in ANPEP (ananyl aminopeptidase) (P = 1.44 × 10-4; OR, 0.69 [95{\%} CI, .56-.83]). Additional genotyping of these SNPs in a separate sample of 264 case patients and 296 control patients resulted in a lack of significance in the replication cohort; joint significance was as follows: rs2066786, P = .0022; rs2298771, P = .005; rs25651, P = .042. Using mostly nonsynonymous variants, we therefore did not identify genetic variants associated with neuroinvasive disease.",
author = "Mark Loeb and Sasha Eskandarian and Rupp, {Mark Edmund} and Neil Fishman and Leanne Gasink and Jan Patterson and Jonathan Bramson and Hudson, {Thomas J.} and Mathieu Lemire",
year = "2011",
month = "10",
day = "1",
doi = "10.1093/infdis/jir493",
language = "English (US)",
volume = "204",
pages = "1031--1037",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "7",

}

TY - JOUR

T1 - Genetic variants and susceptibility to neurological complications following West Nile virus infection

AU - Loeb, Mark

AU - Eskandarian, Sasha

AU - Rupp, Mark Edmund

AU - Fishman, Neil

AU - Gasink, Leanne

AU - Patterson, Jan

AU - Bramson, Jonathan

AU - Hudson, Thomas J.

AU - Lemire, Mathieu

PY - 2011/10/1

Y1 - 2011/10/1

N2 - To determine genetic factors predisposing to neurological complications following West Nile virus infection, we analyzed a cohort of 560 neuroinvasive case patients and 950 control patients for 13 371 mostly nonsynonymous single-nucleotide polymorphisms (SNPs). The top 3 SNPs on the basis of statistical significance were also in genes of biological plausibility: rs2066786 in RFC1 (replication factor C1) (P= 1.88×10-5; odds ratio [OR], 0.68 [95% confidence interval {CI}, .56-.81]); rs2298771 in SCN1A (sodium channel, neuronal type I a subunit) (P = 5.87 × 10-5; OR, 1.47 [95% CI, 1.21-1.77]); and rs25651 in ANPEP (ananyl aminopeptidase) (P = 1.44 × 10-4; OR, 0.69 [95% CI, .56-.83]). Additional genotyping of these SNPs in a separate sample of 264 case patients and 296 control patients resulted in a lack of significance in the replication cohort; joint significance was as follows: rs2066786, P = .0022; rs2298771, P = .005; rs25651, P = .042. Using mostly nonsynonymous variants, we therefore did not identify genetic variants associated with neuroinvasive disease.

AB - To determine genetic factors predisposing to neurological complications following West Nile virus infection, we analyzed a cohort of 560 neuroinvasive case patients and 950 control patients for 13 371 mostly nonsynonymous single-nucleotide polymorphisms (SNPs). The top 3 SNPs on the basis of statistical significance were also in genes of biological plausibility: rs2066786 in RFC1 (replication factor C1) (P= 1.88×10-5; odds ratio [OR], 0.68 [95% confidence interval {CI}, .56-.81]); rs2298771 in SCN1A (sodium channel, neuronal type I a subunit) (P = 5.87 × 10-5; OR, 1.47 [95% CI, 1.21-1.77]); and rs25651 in ANPEP (ananyl aminopeptidase) (P = 1.44 × 10-4; OR, 0.69 [95% CI, .56-.83]). Additional genotyping of these SNPs in a separate sample of 264 case patients and 296 control patients resulted in a lack of significance in the replication cohort; joint significance was as follows: rs2066786, P = .0022; rs2298771, P = .005; rs25651, P = .042. Using mostly nonsynonymous variants, we therefore did not identify genetic variants associated with neuroinvasive disease.

UR - http://www.scopus.com/inward/record.url?scp=80052425321&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052425321&partnerID=8YFLogxK

U2 - 10.1093/infdis/jir493

DO - 10.1093/infdis/jir493

M3 - Article

C2 - 21881118

AN - SCOPUS:80052425321

VL - 204

SP - 1031

EP - 1037

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 7

ER -