Genetic variance and covariance patterns for body weight and energy balance characters in an advanced intercross population of mice

Larry J. Leamy, Kari Elo, Merlyn K Nielsen, L. Dale Van Vleck, Daniel Pomp

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We estimated heritabilities and genetic correlations for a suite of 15 characters in five functional groups in an advanced intercross population of over 2000 mice derived from a cross of inbred lines selected for high and low heat loss. Heritabilities averaged 0.56 for three body weights, 0.23 for two energy balance characters, 0.48 for three bone characters, 0.35 for four measures of adiposity, and 0.27 for three organ weights, all of which were generally consistent in magnitude with estimates derived in previous studies. Genetic correlations varied from -0.65 to +0.98, and were higher within these functional groups than between groups. These correlations generally conformed to a priori expectations, being positive in sign for energy expenditure and consumption (+0.24) and negative in sign for energy expenditure and adiposity (-0.17). The genetic correlations of adiposity with body weight at 3, 6, and 12 weeks of age (-0.29, -0.22, -0.26) all were negative in sign but not statistically significant. The independence of body weight and adiposity suggests that this advanced intercross population is ideal for a comprehensive discovery of genes controlling regulation of mammalian adiposity that are distinct from those for body weight.

Original languageEnglish (US)
Pages (from-to)151-173
Number of pages23
JournalGenetics Selection Evolution
Volume37
Issue number2
DOIs
StatePublished - Mar 1 2005

Fingerprint

genetic covariance
Adiposity
adiposity
genetic variance
energy balance
Body Weight
body weight
genetic correlation
mice
Population
heritability
energy expenditure
Energy Metabolism
functional group
expenditure
Organ Size
Genetic Association Studies
tissue weight
inbred lines
energy

Keywords

  • Advanced intercross mice
  • Body weight
  • Genetic correlations
  • Heritability
  • Obesity

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Animal Science and Zoology
  • Genetics

Cite this

Genetic variance and covariance patterns for body weight and energy balance characters in an advanced intercross population of mice. / Leamy, Larry J.; Elo, Kari; Nielsen, Merlyn K; Van Vleck, L. Dale; Pomp, Daniel.

In: Genetics Selection Evolution, Vol. 37, No. 2, 01.03.2005, p. 151-173.

Research output: Contribution to journalArticle

Leamy, Larry J. ; Elo, Kari ; Nielsen, Merlyn K ; Van Vleck, L. Dale ; Pomp, Daniel. / Genetic variance and covariance patterns for body weight and energy balance characters in an advanced intercross population of mice. In: Genetics Selection Evolution. 2005 ; Vol. 37, No. 2. pp. 151-173.
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