Genetic toxicology of folpet and captan

Gail T. Arce, Elliot B. Gordon, Samuel Monroe Cohen, Pramila Singh

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Folpet and captan are fungicides whose genotoxicity depends on their chemical reaction with thiols. Multiple mutagenicity tests have been conducted on these compounds due to their positive activity in vitro and their association with gastrointestinal tumors in mice. A review of the collective data shows that these compounds have in vitro mutagenic activity but are not genotoxic in vivo. This dichotomy is primarily due to the rapid degradation of folpet and captan in the presence of thiol-rich matrices typically found in vivo. Genotoxicity has not been found in the duodenum, the mouse tumor target tissue. It is concluded that folpet like captan presents an unlikely risk of genotoxic effects in humans.

Original languageEnglish (US)
Pages (from-to)546-574
Number of pages29
JournalCritical reviews in toxicology
Volume40
Issue number6
DOIs
StatePublished - Jan 1 2010

Fingerprint

Captan
Toxicology
Sulfhydryl Compounds
Tumors
Mutagenicity Tests
Fungicides
Duodenum
Chemical reactions
Neoplasms
Association reactions
Tissue
Degradation
folpet
In Vitro Techniques

Keywords

  • Captan
  • duodenum
  • folpet
  • genetic toxicology
  • mutagenicity

ASJC Scopus subject areas

  • Toxicology

Cite this

Genetic toxicology of folpet and captan. / Arce, Gail T.; Gordon, Elliot B.; Cohen, Samuel Monroe; Singh, Pramila.

In: Critical reviews in toxicology, Vol. 40, No. 6, 01.01.2010, p. 546-574.

Research output: Contribution to journalReview article

Arce, Gail T. ; Gordon, Elliot B. ; Cohen, Samuel Monroe ; Singh, Pramila. / Genetic toxicology of folpet and captan. In: Critical reviews in toxicology. 2010 ; Vol. 40, No. 6. pp. 546-574.
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