Genetic-epidemiologic study of early-onset ischemic heart disease

J. J. Nora, R. H. Lortscher, R. D. Spangler, A. H. Nora, W. J. Kimberling

Research output: Contribution to journalArticle

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Abstract

A genetic-epidemiologic study was undertaken of a white Colorado population of 207 patients who had a myocardial infarction before age 55 years. Nineteen independent variables were compared between the 207 cases and 621 controls, matched 3:1. The highest risk ratios were associated with a positive family history for ischemic heart disease (IHD). The heritability of IHD was 63% when families with the monogenic forms of hyperlipoproteinemia were included, and 56% when they were excluded. A risk index was developed that incorporates family history into a data base of risk factors, which can be readily assessed by the clinician obtaining a screening history, physical and standard laboratory tests. A scale of 0-10 was devised and the predictive value of the index was tested against another data set. The efficiency of the index was maximal at a screening level of 5. This study suggests that it is logistically feasible to seek patients at high risk for intensive management in a clinical setting (high-risk strategy) using risk indices similar to the one developed for this study, which emphasize the very important familial component to IHD.

Original languageEnglish (US)
Pages (from-to)503-508
Number of pages6
JournalCirculation
Volume61
Issue number3
DOIs
StatePublished - Jan 1 1980

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Myocardial Ischemia
Epidemiologic Studies
Hyperlipoproteinemias
Risk Management
History
Odds Ratio
Myocardial Infarction
Databases
Population
Datasets

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Nora, J. J., Lortscher, R. H., Spangler, R. D., Nora, A. H., & Kimberling, W. J. (1980). Genetic-epidemiologic study of early-onset ischemic heart disease. Circulation, 61(3), 503-508. https://doi.org/10.1161/01.CIR.61.3.503

Genetic-epidemiologic study of early-onset ischemic heart disease. / Nora, J. J.; Lortscher, R. H.; Spangler, R. D.; Nora, A. H.; Kimberling, W. J.

In: Circulation, Vol. 61, No. 3, 01.01.1980, p. 503-508.

Research output: Contribution to journalArticle

Nora, JJ, Lortscher, RH, Spangler, RD, Nora, AH & Kimberling, WJ 1980, 'Genetic-epidemiologic study of early-onset ischemic heart disease', Circulation, vol. 61, no. 3, pp. 503-508. https://doi.org/10.1161/01.CIR.61.3.503
Nora JJ, Lortscher RH, Spangler RD, Nora AH, Kimberling WJ. Genetic-epidemiologic study of early-onset ischemic heart disease. Circulation. 1980 Jan 1;61(3):503-508. https://doi.org/10.1161/01.CIR.61.3.503
Nora, J. J. ; Lortscher, R. H. ; Spangler, R. D. ; Nora, A. H. ; Kimberling, W. J. / Genetic-epidemiologic study of early-onset ischemic heart disease. In: Circulation. 1980 ; Vol. 61, No. 3. pp. 503-508.
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