Genetic and clinical features of sensorineural hearing loss associated with the 1555 mitochondrial mutation

Shin Ichi Usami, Satoko Abe, Miyo Kasai, Hideichi Shinkawa, Benjamin Moeller, Judy B. Kenyon, William J Kimberling

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

Five Japanese families showing aminoglycoside-induced hearing loss were genetically as well as clinically investigated. A mitochondrial mutation at nucleotide 1555 was found in 28 out of 32 subjects. One hundred American control subjects did not show any evidence of the mutation at nucleotide 1555, suggesting that the 1555 A→G (A1555G) mitochondrial mutation may be found more frequently among populations in the Asian continent. Many subjects who harbor this mitochondrial mutation exhibit a mild, high-frequency, progressive hearing loss even without aminoglycoside injection. The resuits presented here appear to support the hypothesis that the A1555G mutation may play a more general role in causing hearing loss.

Original languageEnglish (US)
Pages (from-to)483-490
Number of pages8
JournalLaryngoscope
Volume107
Issue number4
DOIs
StatePublished - Apr 1 1997

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Sensorineural Hearing Loss
Mutation
Aminoglycosides
Hearing Loss
Nucleotides
High-Frequency Hearing Loss
Injections
Population

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Usami, S. I., Abe, S., Kasai, M., Shinkawa, H., Moeller, B., Kenyon, J. B., & Kimberling, W. J. (1997). Genetic and clinical features of sensorineural hearing loss associated with the 1555 mitochondrial mutation. Laryngoscope, 107(4), 483-490. https://doi.org/10.1097/00005537-199704000-00011

Genetic and clinical features of sensorineural hearing loss associated with the 1555 mitochondrial mutation. / Usami, Shin Ichi; Abe, Satoko; Kasai, Miyo; Shinkawa, Hideichi; Moeller, Benjamin; Kenyon, Judy B.; Kimberling, William J.

In: Laryngoscope, Vol. 107, No. 4, 01.04.1997, p. 483-490.

Research output: Contribution to journalArticle

Usami, SI, Abe, S, Kasai, M, Shinkawa, H, Moeller, B, Kenyon, JB & Kimberling, WJ 1997, 'Genetic and clinical features of sensorineural hearing loss associated with the 1555 mitochondrial mutation', Laryngoscope, vol. 107, no. 4, pp. 483-490. https://doi.org/10.1097/00005537-199704000-00011
Usami, Shin Ichi ; Abe, Satoko ; Kasai, Miyo ; Shinkawa, Hideichi ; Moeller, Benjamin ; Kenyon, Judy B. ; Kimberling, William J. / Genetic and clinical features of sensorineural hearing loss associated with the 1555 mitochondrial mutation. In: Laryngoscope. 1997 ; Vol. 107, No. 4. pp. 483-490.
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