Genetic analysis of dyslexia and other complex behavioral phenotypes

Bruce F. Pennington, Shelley D. Smith

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

In this review, we discuss recent data on the genetics of developmental dyslexia and consider broader issues involved in the search for genes influencing complex behavioral phenotypes. These issues include 1) the need for a sophisticated analysis of the phenotype and the need for interdisciplinary collaboration between geneticists and cognitive neuroscientists, 2) the likelihood of genetic heterogeneity and non-Mendelian inheritance and the necessity for linkage methods to deal with these issues, and 3) how association analyses complement linkage analyses.

Original languageEnglish (US)
Pages (from-to)636-641
Number of pages6
JournalCurrent Opinion in Pediatrics
Volume9
Issue number6
DOIs
StatePublished - Jan 1 1997

Fingerprint

Dyslexia
Phenotype
Genetic Heterogeneity
Genes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Genetic analysis of dyslexia and other complex behavioral phenotypes. / Pennington, Bruce F.; Smith, Shelley D.

In: Current Opinion in Pediatrics, Vol. 9, No. 6, 01.01.1997, p. 636-641.

Research output: Contribution to journalReview article

@article{c39c244669ad493a8c261552bf67026c,
title = "Genetic analysis of dyslexia and other complex behavioral phenotypes",
abstract = "In this review, we discuss recent data on the genetics of developmental dyslexia and consider broader issues involved in the search for genes influencing complex behavioral phenotypes. These issues include 1) the need for a sophisticated analysis of the phenotype and the need for interdisciplinary collaboration between geneticists and cognitive neuroscientists, 2) the likelihood of genetic heterogeneity and non-Mendelian inheritance and the necessity for linkage methods to deal with these issues, and 3) how association analyses complement linkage analyses.",
author = "Pennington, {Bruce F.} and Smith, {Shelley D.}",
year = "1997",
month = "1",
day = "1",
doi = "10.1097/00008480-199712000-00014",
language = "English (US)",
volume = "9",
pages = "636--641",
journal = "Current Opinion in Pediatrics",
issn = "1040-8703",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Genetic analysis of dyslexia and other complex behavioral phenotypes

AU - Pennington, Bruce F.

AU - Smith, Shelley D.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - In this review, we discuss recent data on the genetics of developmental dyslexia and consider broader issues involved in the search for genes influencing complex behavioral phenotypes. These issues include 1) the need for a sophisticated analysis of the phenotype and the need for interdisciplinary collaboration between geneticists and cognitive neuroscientists, 2) the likelihood of genetic heterogeneity and non-Mendelian inheritance and the necessity for linkage methods to deal with these issues, and 3) how association analyses complement linkage analyses.

AB - In this review, we discuss recent data on the genetics of developmental dyslexia and consider broader issues involved in the search for genes influencing complex behavioral phenotypes. These issues include 1) the need for a sophisticated analysis of the phenotype and the need for interdisciplinary collaboration between geneticists and cognitive neuroscientists, 2) the likelihood of genetic heterogeneity and non-Mendelian inheritance and the necessity for linkage methods to deal with these issues, and 3) how association analyses complement linkage analyses.

UR - http://www.scopus.com/inward/record.url?scp=0031436594&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031436594&partnerID=8YFLogxK

U2 - 10.1097/00008480-199712000-00014

DO - 10.1097/00008480-199712000-00014

M3 - Review article

C2 - 9425598

AN - SCOPUS:0031436594

VL - 9

SP - 636

EP - 641

JO - Current Opinion in Pediatrics

JF - Current Opinion in Pediatrics

SN - 1040-8703

IS - 6

ER -