Generation of osteoporosis in immune-compromised mice for stem cell therapy

Reeva Aggarwal, Vincent J. Pompili, Hiranmoy Das

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

To evaluate therapeutic efficacy and to investigate involved molecular mechanisms of cell-based therapy in osteoporosis, the generation of a clinically relevant model is critically important. Herein, we describe detailed methods in generation of an immune-deficient osteoporotic murine model, and application of human umbilical cord blood-derived stem cells to assess their therapeutic efficacy.

Original languageEnglish (US)
Pages (from-to)209-214
Number of pages6
JournalMethods in Molecular Biology
Volume1213
DOIs
StatePublished - Jan 1 2014

Fingerprint

Cell- and Tissue-Based Therapy
Osteoporosis
Stem Cells
Fetal Blood
Therapeutics

Keywords

  • Intramyocardial injection
  • NOD/SCID mice
  • Osteoporosis
  • Stem cells

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Generation of osteoporosis in immune-compromised mice for stem cell therapy. / Aggarwal, Reeva; Pompili, Vincent J.; Das, Hiranmoy.

In: Methods in Molecular Biology, Vol. 1213, 01.01.2014, p. 209-214.

Research output: Contribution to journalArticle

Aggarwal, Reeva ; Pompili, Vincent J. ; Das, Hiranmoy. / Generation of osteoporosis in immune-compromised mice for stem cell therapy. In: Methods in Molecular Biology. 2014 ; Vol. 1213. pp. 209-214.
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