Generation and characterization of monoclonal antibodies against the proregion of human desmoglein-2

Sarah A. Keim, Keith R Johnson, Margaret J. Wheelock, James K Wahl

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10 Scopus citations

Abstract

Cadherins are synthesized with a signal sequence and a proregion that must be removed for optimal adhesive activity. Mutations that prevent processing of cadherins have been implicated in a number of human diseases; thus understanding their processing is critical. In this study, we produced and characterized a number of monoclonal antibodies against the proregion of the desmosomal cadherin, human desmoglein-2, that will facilitate investigations into the processing of this protein.

Original languageEnglish (US)
Pages (from-to)249-258
Number of pages10
JournalHybridoma
Volume27
Issue number4
DOIs
Publication statusPublished - Aug 1 2008

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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