Inactivación de genes de Mycobacterium tuberculosis y su potencial utilidad en la prevención y el control de la tuberculosis.

Translated title of the contribution: Gene inactivation in Mycobacterium tuberculosis and its use in tuberculosis control and prevention

Ofelia Chacón, Teresa Realpe, Raúl Gerardo Barletta, Jaime Robledo

Research output: Contribution to journalReview article

Abstract

Availability of the M. tuberculosis genome sequence and the development of sophisticated systems for genetic manipulation of bacilli offer the potential for new and effective tools to prevent and control tuberculosis. Efficient methods to inactivate mycobacterial genes have been developed. These methods have become the cornerstone for the application and development of mycobacterial functional genomics. Specific mutants are generated to establish the role of targetted genes associated with mycobacterial physiology and pathogenesis. Gene inactivation, supported directly or indirectly by the deciphering of the mycobacterial genome, has permitted the generation of large numbers of M. tuberculosis mutants. Analysis of these mutants has (in some cases) established relationships between gene products and their role in mycobacterial physiology and pathogenesis.

Original languageSpanish
Pages (from-to)165-187
Number of pages23
JournalBiomédica : revista del Instituto Nacional de Salud
Volume24 Supp 1
StatePublished - Jun 2004

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Gene Silencing
Mycobacterium tuberculosis
Tuberculosis
Genes
Genome
Physiology
Genomics
Bacillus
Bacilli
Availability

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Inactivación de genes de Mycobacterium tuberculosis y su potencial utilidad en la prevención y el control de la tuberculosis. / Chacón, Ofelia; Realpe, Teresa; Barletta, Raúl Gerardo; Robledo, Jaime.

In: Biomédica : revista del Instituto Nacional de Salud, Vol. 24 Supp 1, 06.2004, p. 165-187.

Research output: Contribution to journalReview article

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