Gene flow mediates the role of sex chromosome meiotic drive during complex speciation

Colin D. Meiklejohn, Emily L. Landeen, Kathleen E. Gordon, Thomas Rzatkiewicz, Sarah B. Kingan, Anthony J. Geneva, Jeffrey P. Vedanayagam, Christina A. Muirhead, Daniel Garrigan, David L. Stern, Daven C. Presgraves

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

During speciation, sex chromosomes often accumulate interspecific genetic incompatibilities faster than the rest of the genome. The drive theory posits that sex chromosomes are susceptible to recurrent bouts of meiotic drive and suppression, causing the evolutionary buildup of divergent cryptic sex-linked drive systems and, incidentally, genetic incompatibilities. To assess the role of drive during speciation, we combine high-resolution genetic mapping of X-linked hybrid male sterility with population genomics analyses of divergence and recent gene flow between the fruitfly species, Drosophila mauritiana and D. simulans. Our findings reveal a high density of genetic incompatibilities and a corresponding dearth of gene flow on the X chromosome. Surprisingly, we find that a known drive element recently migrated between species and, rather than contributing to interspecific divergence, caused a strong reduction in local sequence divergence, undermining the evolution of hybrid sterility. Gene flow can therefore mediate the effects of selfish genetic elements during speciation.

Original languageEnglish (US)
Article numbere35468
JournaleLife
Volume7
DOIs
StatePublished - Dec 1 2018

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Sex Chromosomes
Gene Flow
Genes
Metagenomics
Male Infertility
X Chromosome
Infertility
Drosophila
Genome
Chromosomes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Meiklejohn, C. D., Landeen, E. L., Gordon, K. E., Rzatkiewicz, T., Kingan, S. B., Geneva, A. J., ... Presgraves, D. C. (2018). Gene flow mediates the role of sex chromosome meiotic drive during complex speciation. eLife, 7, [e35468]. https://doi.org/10.7554/eLife.35468

Gene flow mediates the role of sex chromosome meiotic drive during complex speciation. / Meiklejohn, Colin D.; Landeen, Emily L.; Gordon, Kathleen E.; Rzatkiewicz, Thomas; Kingan, Sarah B.; Geneva, Anthony J.; Vedanayagam, Jeffrey P.; Muirhead, Christina A.; Garrigan, Daniel; Stern, David L.; Presgraves, Daven C.

In: eLife, Vol. 7, e35468, 01.12.2018.

Research output: Contribution to journalArticle

Meiklejohn, CD, Landeen, EL, Gordon, KE, Rzatkiewicz, T, Kingan, SB, Geneva, AJ, Vedanayagam, JP, Muirhead, CA, Garrigan, D, Stern, DL & Presgraves, DC 2018, 'Gene flow mediates the role of sex chromosome meiotic drive during complex speciation', eLife, vol. 7, e35468. https://doi.org/10.7554/eLife.35468
Meiklejohn CD, Landeen EL, Gordon KE, Rzatkiewicz T, Kingan SB, Geneva AJ et al. Gene flow mediates the role of sex chromosome meiotic drive during complex speciation. eLife. 2018 Dec 1;7. e35468. https://doi.org/10.7554/eLife.35468
Meiklejohn, Colin D. ; Landeen, Emily L. ; Gordon, Kathleen E. ; Rzatkiewicz, Thomas ; Kingan, Sarah B. ; Geneva, Anthony J. ; Vedanayagam, Jeffrey P. ; Muirhead, Christina A. ; Garrigan, Daniel ; Stern, David L. ; Presgraves, Daven C. / Gene flow mediates the role of sex chromosome meiotic drive during complex speciation. In: eLife. 2018 ; Vol. 7.
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