Gene expression profiling with DNA microarrays

Advancing our understanding of psychiatric disorders

Julie Pongrac, Frank A. Middleton, David A. Lewis, Pat Levitt, Karoly Mirnics

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

DNA microarray transcriptome profiling of the postmortem brain opens novel horizons in understanding molecular changes associated with complex psychiatric disorders. With careful analysis and interpretation of microarray data we are uncovering previously unknown, expression patterns that maybe subject-specific and pivotal in understanding the disease process. In our recent studies, analyses of the prefrontal cortex of subjects with schizophrenia and matched controls uncovered complex changes in the expression of genes related to presynaptic secretory release, GABAergic and glutamatergic transmission, metabolic pathways, myelination, as well as cAMP and phosphoinositol second messenger systems. Our goal will be to integrate this expression data within the context of the relevant anatomical, biochemical, molecular, imaging and clinical findings.

Original languageEnglish (US)
Pages (from-to)1049-1063
Number of pages15
JournalNeurochemical Research
Volume27
Issue number10
DOIs
StatePublished - Oct 1 2002

Fingerprint

Molecular Imaging
Second Messenger Systems
Gene Expression Profiling
Microarray Analysis
Microarrays
Metabolic Networks and Pathways
Oligonucleotide Array Sequence Analysis
Prefrontal Cortex
Gene expression
Psychiatry
Schizophrenia
Molecular imaging
Gene Expression
DNA
Brain
Genes

Keywords

  • Expression
  • Gene
  • Human
  • Microarray
  • Profiling
  • Psychiatric

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Gene expression profiling with DNA microarrays : Advancing our understanding of psychiatric disorders. / Pongrac, Julie; Middleton, Frank A.; Lewis, David A.; Levitt, Pat; Mirnics, Karoly.

In: Neurochemical Research, Vol. 27, No. 10, 01.10.2002, p. 1049-1063.

Research output: Contribution to journalArticle

Pongrac, Julie ; Middleton, Frank A. ; Lewis, David A. ; Levitt, Pat ; Mirnics, Karoly. / Gene expression profiling with DNA microarrays : Advancing our understanding of psychiatric disorders. In: Neurochemical Research. 2002 ; Vol. 27, No. 10. pp. 1049-1063.
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