Gene × Environment interactions in speech sound disorder predict language and preliteracy outcomes

Lauren M. McGrath, Bruce F. Pennington, Erik G. Wtllcutt, Richard Boada, Lawrence D. Shriberg, Shelley D Smith

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Few studies have investigated the role of genebenvironment interactions (G × E) in speech, language, and literacy disorders. Currently, there are two theoretical models, the diathesis-stress model and the bioecological model, that make opposite predictions about the expected direction of G × E, because environmental risk factors may either strengthen or weaken the effect of genes on phenotypes. The purpose of the current study was to test for G × E at two speech sound disorder and reading disability linkage peaks using a sib-pair linkage design and continuous measures of socioeconomic status, home language/literacy environment, and number of ear infections. The interactions were tested using composite speech, language, and preliteracy phenotypes and previously identified linkage peaks on 6p22 and 15q21. Results showed five G × E at both the 6p22 and 15q21 locations across several phenotypes and environmental measures. Four of the five interactions were consistent with the bioecological model of G × E. Each of these four interactions involved environmental measures of the home language/literacy environment. The only interaction that was consistent with the diathesis-stress model was one involving the number of ear infections as the environmental risk variable. The direction of these interactions and possible interpretations are explored in the discussion.

Original languageEnglish (US)
Pages (from-to)1047-1072
Number of pages26
JournalDevelopment and psychopathology
Volume19
Issue number4
DOIs
StatePublished - Sep 1 2007

Fingerprint

Gene-Environment Interaction
Language
Disease Susceptibility
Phenotype
Ear
Language Disorders
Infection
Social Class
Reading
Theoretical Models
Genes
Speech Sound Disorder
Literacy
Direction compound

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this

Gene × Environment interactions in speech sound disorder predict language and preliteracy outcomes. / McGrath, Lauren M.; Pennington, Bruce F.; Wtllcutt, Erik G.; Boada, Richard; Shriberg, Lawrence D.; Smith, Shelley D.

In: Development and psychopathology, Vol. 19, No. 4, 01.09.2007, p. 1047-1072.

Research output: Contribution to journalArticle

McGrath, Lauren M. ; Pennington, Bruce F. ; Wtllcutt, Erik G. ; Boada, Richard ; Shriberg, Lawrence D. ; Smith, Shelley D. / Gene × Environment interactions in speech sound disorder predict language and preliteracy outcomes. In: Development and psychopathology. 2007 ; Vol. 19, No. 4. pp. 1047-1072.
@article{0770e0a4ad62469aae1ba018b5068b92,
title = "Gene × Environment interactions in speech sound disorder predict language and preliteracy outcomes",
abstract = "Few studies have investigated the role of genebenvironment interactions (G × E) in speech, language, and literacy disorders. Currently, there are two theoretical models, the diathesis-stress model and the bioecological model, that make opposite predictions about the expected direction of G × E, because environmental risk factors may either strengthen or weaken the effect of genes on phenotypes. The purpose of the current study was to test for G × E at two speech sound disorder and reading disability linkage peaks using a sib-pair linkage design and continuous measures of socioeconomic status, home language/literacy environment, and number of ear infections. The interactions were tested using composite speech, language, and preliteracy phenotypes and previously identified linkage peaks on 6p22 and 15q21. Results showed five G × E at both the 6p22 and 15q21 locations across several phenotypes and environmental measures. Four of the five interactions were consistent with the bioecological model of G × E. Each of these four interactions involved environmental measures of the home language/literacy environment. The only interaction that was consistent with the diathesis-stress model was one involving the number of ear infections as the environmental risk variable. The direction of these interactions and possible interpretations are explored in the discussion.",
author = "McGrath, {Lauren M.} and Pennington, {Bruce F.} and Wtllcutt, {Erik G.} and Richard Boada and Shriberg, {Lawrence D.} and Smith, {Shelley D}",
year = "2007",
month = "9",
day = "1",
doi = "10.1017/S0954579407000533",
language = "English (US)",
volume = "19",
pages = "1047--1072",
journal = "Development and Psychopathology",
issn = "0954-5794",
publisher = "Cambridge University Press",
number = "4",

}

TY - JOUR

T1 - Gene × Environment interactions in speech sound disorder predict language and preliteracy outcomes

AU - McGrath, Lauren M.

AU - Pennington, Bruce F.

AU - Wtllcutt, Erik G.

AU - Boada, Richard

AU - Shriberg, Lawrence D.

AU - Smith, Shelley D

PY - 2007/9/1

Y1 - 2007/9/1

N2 - Few studies have investigated the role of genebenvironment interactions (G × E) in speech, language, and literacy disorders. Currently, there are two theoretical models, the diathesis-stress model and the bioecological model, that make opposite predictions about the expected direction of G × E, because environmental risk factors may either strengthen or weaken the effect of genes on phenotypes. The purpose of the current study was to test for G × E at two speech sound disorder and reading disability linkage peaks using a sib-pair linkage design and continuous measures of socioeconomic status, home language/literacy environment, and number of ear infections. The interactions were tested using composite speech, language, and preliteracy phenotypes and previously identified linkage peaks on 6p22 and 15q21. Results showed five G × E at both the 6p22 and 15q21 locations across several phenotypes and environmental measures. Four of the five interactions were consistent with the bioecological model of G × E. Each of these four interactions involved environmental measures of the home language/literacy environment. The only interaction that was consistent with the diathesis-stress model was one involving the number of ear infections as the environmental risk variable. The direction of these interactions and possible interpretations are explored in the discussion.

AB - Few studies have investigated the role of genebenvironment interactions (G × E) in speech, language, and literacy disorders. Currently, there are two theoretical models, the diathesis-stress model and the bioecological model, that make opposite predictions about the expected direction of G × E, because environmental risk factors may either strengthen or weaken the effect of genes on phenotypes. The purpose of the current study was to test for G × E at two speech sound disorder and reading disability linkage peaks using a sib-pair linkage design and continuous measures of socioeconomic status, home language/literacy environment, and number of ear infections. The interactions were tested using composite speech, language, and preliteracy phenotypes and previously identified linkage peaks on 6p22 and 15q21. Results showed five G × E at both the 6p22 and 15q21 locations across several phenotypes and environmental measures. Four of the five interactions were consistent with the bioecological model of G × E. Each of these four interactions involved environmental measures of the home language/literacy environment. The only interaction that was consistent with the diathesis-stress model was one involving the number of ear infections as the environmental risk variable. The direction of these interactions and possible interpretations are explored in the discussion.

UR - http://www.scopus.com/inward/record.url?scp=35348864391&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35348864391&partnerID=8YFLogxK

U2 - 10.1017/S0954579407000533

DO - 10.1017/S0954579407000533

M3 - Article

C2 - 17931434

AN - SCOPUS:35348864391

VL - 19

SP - 1047

EP - 1072

JO - Development and Psychopathology

JF - Development and Psychopathology

SN - 0954-5794

IS - 4

ER -