Gene duplication and the evolution of hemoglobin isoform differentiation in birds

Michael T. Grispo, Chandrasekhar Natarajan, Joana Projecto-Garcia, Hideaki Moriyama, Roy E. Weber, Jay F Storz

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: The functional significance of hemoglobin heterogeneity remains a mystery. Results: In adult birds, the HbD isoform (related to embryonic hemoglobin) exhibits distinct oxygenation properties relative to the major HbA isoform. Conclusion: Substitutions that distinguish HbD from HbA are not shared with embryonic hemoglobin. Significance: Differences between isoforms stem from derived (nonancestral) changes in duplicated genes, not from the retention of an ancestral condition.

Original languageEnglish (US)
Pages (from-to)37647-37658
Number of pages12
JournalJournal of Biological Chemistry
Volume287
Issue number45
DOIs
StatePublished - Nov 2 2012

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Gene Duplication
Birds
Protein Isoforms
Hemoglobins
Genes
Oxygenation
Substitution reactions

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Gene duplication and the evolution of hemoglobin isoform differentiation in birds. / Grispo, Michael T.; Natarajan, Chandrasekhar; Projecto-Garcia, Joana; Moriyama, Hideaki; Weber, Roy E.; Storz, Jay F.

In: Journal of Biological Chemistry, Vol. 287, No. 45, 02.11.2012, p. 37647-37658.

Research output: Contribution to journalArticle

Grispo, Michael T. ; Natarajan, Chandrasekhar ; Projecto-Garcia, Joana ; Moriyama, Hideaki ; Weber, Roy E. ; Storz, Jay F. / Gene duplication and the evolution of hemoglobin isoform differentiation in birds. In: Journal of Biological Chemistry. 2012 ; Vol. 287, No. 45. pp. 37647-37658.
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